Background: Drosophila trpml mutants reproduced many defects associated with mucolipidosis type IV, but the flyTRPML channel remains uncharacterized. Results: Drosophila TRPML is a phosphoinositide-regulated cation channel on endolysosome and plasma membranes. Conclusion: Fly TRPML largely resembles mammalian TRPML1, but exhibits differences in subcellular localization and pH dependence. Significance: The data support using Drosophila for assessing TRPML1 function.
|Original language||English (US)|
|Number of pages||11|
|Journal||Journal of Biological Chemistry|
|State||Published - Feb 14 2014|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology