Downbeat down south

Ying Chen; Michael L. Morgan; Angelina Espino Barros Palau; Janice A. Mudd; Andrew G. Lee; Jason J S Barton

doi:10.1016/j.survophthal.2014.06.004

Downbeat down south

Ying Chen, Michael L. Morgan, Angelina Espino Barros Palau, Janice A. Mudd, Andrew G. Lee, Jason J S Barton

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A 59-year-old woman with late-onset diabetes mellitus presented with a 4-week history of oscillopsia and vertigo. Physical examination revealed downbeating nystagmus in the primary position that worsened on right gaze and left gaze. Magnetic resonance imaging of the brain and orbits showed enhancement and signal abnormality in the right temporal lobe without evidence of a cervicomedullary junction lesion. Serum anti-glutamic acid decarboxylase 65 (GAD65) antibody titer was markedly elevated. Given these findings, her vertigo and downbeat nystagmus were likely secondary to elevated anti-GAD antibodies.

Original language	English (US)
Pages (from-to)	177-181
Number of pages	5
Journal	Survey of Ophthalmology
Volume	60
Issue number	2
DOIs	https://doi.org/10.1016/j.survophthal.2014.06.004
State	Published - Mar 1 2015

Keywords

Anti-GAD antibodies
Autoimmune disease
Downbeat nystagmus
Magnetic resonance imaging

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.survophthal.2014.06.004

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title = "Downbeat down south",

abstract = "A 59-year-old woman with late-onset diabetes mellitus presented with a 4-week history of oscillopsia and vertigo. Physical examination revealed downbeating nystagmus in the primary position that worsened on right gaze and left gaze. Magnetic resonance imaging of the brain and orbits showed enhancement and signal abnormality in the right temporal lobe without evidence of a cervicomedullary junction lesion. Serum anti-glutamic acid decarboxylase 65 (GAD65) antibody titer was markedly elevated. Given these findings, her vertigo and downbeat nystagmus were likely secondary to elevated anti-GAD antibodies.",

keywords = "Anti-GAD antibodies, Autoimmune disease, Downbeat nystagmus, Magnetic resonance imaging",

author = "Ying Chen and Morgan, {Michael L.} and {Espino Barros Palau}, Angelina and Mudd, {Janice A.} and Lee, {Andrew G.} and Barton, {Jason J S}",

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T1 - Downbeat down south

AU - Chen, Ying

AU - Morgan, Michael L.

AU - Espino Barros Palau, Angelina

AU - Mudd, Janice A.

AU - Lee, Andrew G.

AU - Barton, Jason J S

PY - 2015/3/1

Y1 - 2015/3/1

N2 - A 59-year-old woman with late-onset diabetes mellitus presented with a 4-week history of oscillopsia and vertigo. Physical examination revealed downbeating nystagmus in the primary position that worsened on right gaze and left gaze. Magnetic resonance imaging of the brain and orbits showed enhancement and signal abnormality in the right temporal lobe without evidence of a cervicomedullary junction lesion. Serum anti-glutamic acid decarboxylase 65 (GAD65) antibody titer was markedly elevated. Given these findings, her vertigo and downbeat nystagmus were likely secondary to elevated anti-GAD antibodies.

AB - A 59-year-old woman with late-onset diabetes mellitus presented with a 4-week history of oscillopsia and vertigo. Physical examination revealed downbeating nystagmus in the primary position that worsened on right gaze and left gaze. Magnetic resonance imaging of the brain and orbits showed enhancement and signal abnormality in the right temporal lobe without evidence of a cervicomedullary junction lesion. Serum anti-glutamic acid decarboxylase 65 (GAD65) antibody titer was markedly elevated. Given these findings, her vertigo and downbeat nystagmus were likely secondary to elevated anti-GAD antibodies.

KW - Anti-GAD antibodies

KW - Autoimmune disease

KW - Downbeat nystagmus

KW - Magnetic resonance imaging

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JO - Survey of Ophthalmology

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Downbeat down south

Abstract

Keywords

ASJC Scopus subject areas

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