Podwójna twarz komórek macierzystych w pediatrii: Zastosowania terapeutyczne mezenchymalnych komórek macierzystych i zagrożenia rakowymi komórkami macierzystymi

Translated title of the contribution: Double face of stem cells in paediatrics: Therapeutic applications of mesenchymal stem cells and threats from cancer stem cells

Ahmed Uosef, R. Mark Ghobrial, Krystyna Jęderka, Anna Puławska-Czub, Slawomir Lewicki, Jacek Z. Kubiak, Malgorzata Kloc

Research output: Contribution to journalArticle

Abstract

Decades of research have shown that many, if not all, fully developed and differentiated organs and tissues contain a subpopulation of undifferentiated stem cells or progenitors of stem cells, which under natural or experimental conditions can self-renew and differentiate into specialised cells. These findings have opened countless possibilities of novel therapeutic applications for the treatment of adult and child diseases. The main sources of stem cells used in paediatric therapies are umbilical cord and umbilical cord blood, amniotic fluid, placenta, bone marrow, adipose tissue, urine, and induced pluripotent stem cells derived from the patient’s cells. Here, we describe some of the paediatrically applicable stem cell therapies. We focus our attention on the therapeutic applications of mesenchymal stem cells in paediatric diseases. An important but negative effect of stem cell therapies is the risk of oncogenic potential of therapeutically applied stem cells. Under certain circumstances, these stem cells can lead to tumour development. In addition, the majority of adult and paediatric tumours contain a subpopulation of cancer stem cells which are privileged therapeutic targets for numerous paediatric cancers. In this article, we review these two opposite properties (“double face”) of stem cells in general and paediatric medicine.

Translated title of the contributionDouble face of stem cells in paediatrics: Therapeutic applications of mesenchymal stem cells and threats from cancer stem cells
Original languagePolish
Pages (from-to)171-174
Number of pages4
JournalPediatria i Medycyna Rodzinna
Volume16
Issue number2
DOIs
StatePublished - 2020

Keywords

  • Cancer stem cells (CSCs)
  • Glioma stem cells (GSCs)
  • Leukaemia stem cells (LSCs)
  • Mesenchymal stem cells (MSCs)
  • Stem cells therapies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Family Practice

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