Dose-response study of intracoronary beta-radiation with 32P in balloon- and stent-injured coronary arteries in swine

Grzegorz L. Ka, Albert E. Raizner, Wojciech Mazur, Daryl G. Schulz, Pawe Zymek, Phong Nguyen-Ho, Fermin O. Tio, Luis F. Fajardo, Nadir M. Ali

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: A dose-response study was performed in swine to investigate the vascular effects of 32P over a broad range of doses in order to define the therapeutic window of intracoronary radiotherapy (ICR) with 32P. Methods and Materials: A total of 131 porcine arteries were subjected to balloon injury or stenting followed by 0-36 Gy of ICR from a centered 32P source wire to 1 mm beyond lumen surface or a sham ICR procedure. Animals were euthanized at 4 weeks, and vessels were harvested for histomorphometry. Results: In the balloon-injured arteries, doses of 7 and 9 Gy did not impact restenosis. At doses of 14-36 Gy, neointima was markedly reduced, with mild dilatation at the highest dose, 36 Gy. In the stent-injured arteries, the lowest dose of 9 Gy failed to reduce neointimal growth, while 14-26 Gy showed the most favorable response. Conclusions: ICR with 32P features a broad therapeutic window. Doses of 14-26 Gy to 1 mm beyond lumen surface provided an optimal combination of efficacy and safety. Doses of 7 and 9 Gy were generally ineffective, suggesting a minimum threshold for ICR with 32P to effectively inhibit restenosis.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalCardiovascular Radiation Medicine
Volume2
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Angioplasty
  • Coronary
  • Radiation
  • Restenosis
  • Stent

ASJC Scopus subject areas

  • Surgery
  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

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