Dose response of adrenocorticotropin and cortisol to the CCK-B agonist pentagastrin

James L. Abelson, Israel Liberzon

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Cholecystokinin (CCK) is an abundant neurotransmitter in brain. Its functional significance in humans is incompletely understood, but it may modulate activity in the hypothalamic-pituitary-adrenal (HPA) axis. To explore this hypothesis, we examined the effects of varying doses (0 to 0.8 μg/kg) of the CCK-B agonist pentagastrin on adrenocorticotropin (ACTH) and cortisol release in healthy human subjects. We also examined anxiety, heart rate (HR), and blood pressure (BP) responses. Pentagastrin induced large (up to 520 % increase over baseline), significant and very rapid, dose-dependent elevations in ACTH and cortisol levels. Significant elevations in HR and BP were seen at all doses, without clear dose-response relationships. Anxious distress and symptom responses were also somewhat dose dependent; but hormonal responses were more robustly linked to pentagastrin dose than to these subjective measures. The HPA axis response to the CCK-B agonist pentagastrin may be a direct pharmacological effect. Further work is needed to determine the mechanisms and the physiological significance of CCK-mediated modulation of the human neuroendocrine stress axis. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
JournalNeuropsychopharmacology
Volume21
Issue number4
DOIs
StatePublished - Oct 1 1999

Keywords

  • Adrenocorticotropin
  • Anxiety
  • Cholecystokinin
  • Cortisol
  • Panic disorder

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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