Dose response of adrenocorticotropin and cortisol to the CCK-B agonist pentagastrin

James L. Abelson, Israel Liberzon

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Cholecystokinin (CCK) is an abundant neurotransmitter in brain. Its functional significance in humans is incompletely understood, but it may modulate activity in the hypothalamic-pituitary-adrenal (HPA) axis. To explore this hypothesis, we examined the effects of varying doses (0 to 0.8 μg/kg) of the CCK-B agonist pentagastrin on adrenocorticotropin (ACTH) and cortisol release in healthy human subjects. We also examined anxiety, heart rate (HR), and blood pressure (BP) responses. Pentagastrin induced large (up to 520 % increase over baseline), significant and very rapid, dose-dependent elevations in ACTH and cortisol levels. Significant elevations in HR and BP were seen at all doses, without clear dose-response relationships. Anxious distress and symptom responses were also somewhat dose dependent; but hormonal responses were more robustly linked to pentagastrin dose than to these subjective measures. The HPA axis response to the CCK-B agonist pentagastrin may be a direct pharmacological effect. Further work is needed to determine the mechanisms and the physiological significance of CCK-mediated modulation of the human neuroendocrine stress axis. Copyright (C) 1999 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
JournalNeuropsychopharmacology
Volume21
Issue number4
DOIs
StatePublished - Oct 1 1999

Keywords

  • Adrenocorticotropin
  • Anxiety
  • Cholecystokinin
  • Cortisol
  • Panic disorder

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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