Dopaminergic deficit is not the rule in orthostatic tremor

Jean Marc Trocello, Paolo Zanotti-Fregonara, Emmanuel Roze, Emmanuelle Apartis, André Pierre Legrand, Marie Odile Habert, Jean Yves Devaux, Marie Vidailhet

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Involvement of the dopaminergic system in orthostatic tremor is controversial. The aim of this study was to detect possible dopaminergic denervation in primary orthostatic tremor (OT). Twelve consecutive patients with a firm diagnosis of primary orthostatic tremor were compared with age-matched normal controls. All the patients had a neurological examination, surface polymyography, and quantification of striatal dopamine transporters with 123I-FP-CIT SPECT imaging. There was no significant difference in 123I-FP-CIT SPECT findings between controls and patients with OT. Longstanding primary orthostatic tremor is not necessarily associated with 123I-FP-CIT SPECT abnormalities, as 8 of our patients had more than a 10-year history of OT. Primary orthostatic tremor without dopaminergic denervation remains a valid entity, although representing only a subtype of high-frequency OT. A new role may emerge for 123I-FP-CIT SPECT in distinguishing between patients whose symptoms will be restricted to OT throughout the disease course and patients at an increased risk of developing PD.

Original languageEnglish (US)
Pages (from-to)1733-1738
Number of pages6
JournalMovement Disorders
Volume23
Issue number12
DOIs
StatePublished - Sep 15 2008

Keywords

  • Neurophysiology
  • Orthostatic tremor
  • Parkinson's disease
  • Pathophysiology
  • Prognosis
  • SPECT

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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