Donor origin of a posttransplant liver allograft malignancy identified by fluorescence in situ hybridization for the y chromosome and DNA genotyping

John A. Donovan, Fred A. Simmons, Karl T. Esrason, Mehdi Jamehdor, Ronald W. Busuttil, Jessicca M. Novak, Wayne W. Grody

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Posttransplantation malignancy in the allograft is a rare complication of orthotopic liver transplantation. In the described case, an abnormal T- tube cholangiogram, performed 6 months after orthotopic liver transplantation between a male donor and a female recipient, prompted needle liver biopsy. A moderately differentiated adenocarcinoma was found. Fluorescence in situ hybridization for the Y chromosome indicated male origin of malignancy. Donor-related disease was confirmed by comparative DNA analysis of genomic sequences from the donor liver, associated tumor, and recipient peripheral blood. Results of these investigations qualified the recipient for a second liver transplant.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalTransplantation
Volume63
Issue number1
DOIs
StatePublished - Jan 15 1997

ASJC Scopus subject areas

  • Transplantation

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