TY - JOUR
T1 - Donor Indocyanine Green Clearance Test Predicts Graft Quality and Early Graft Prognosis After Liver Transplantation
AU - Tang, Yunhua
AU - Han, Ming
AU - Chen, Maogen
AU - Wang, Xiaoping
AU - Ji, Fei
AU - Zhao, Qiang
AU - Zhang, Zhiheng
AU - Ju, Weiqiang
AU - Wang, Dongping
AU - Guo, Zhiyong
AU - He, Xiaoshun
N1 - Funding Information:
Acknowledgments The National Natural Science Foundation of China (81373156, 81401324, 81570587), the Science and Technology Planning Key Clinical Project of Guangdong Province (2016A020215048), the Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology (2013A061401007), and Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation; 2015B050501002) supported this study.
Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background: Transplantation centers have given much attention to donor availability. However, no reliable quantitative methods have been employed to accurately assess graft quality before transplantation. Here, we report that the indocyanine green (ICG) clearance test is a valuable index for liver grafts. Methods: We performed the ICG clearance test on 90 brain-dead donors within 6 h before organ procurement between March 2015 and November 2016. We also analyzed the relationship between graft liver function and early graft survival after liver transplantation (LT). Results: Our results suggest that the ICG retention rate at 15 min (ICGR15) of donors before procurement was independently associated with 3-month graft survival after LT. The best donor ICGR15 cutoff value was 11.0%/min, and we observed a significant increase in 3-month graft failure among patients with a donor ICGR15 above this value. On the other hand, a donor ICGR15 value of ≤ 11.0%/min could be used as an early assessment index of graft quality because it provides additional information to the transplant surgeon or organ procurement organization members who must maintain or improve organ function to adapt the LT. Conclusion: An ICG clearance test before liver procurement might be an effective quantitative method to predict graft availability and improve early graft prognosis after LT.
AB - Background: Transplantation centers have given much attention to donor availability. However, no reliable quantitative methods have been employed to accurately assess graft quality before transplantation. Here, we report that the indocyanine green (ICG) clearance test is a valuable index for liver grafts. Methods: We performed the ICG clearance test on 90 brain-dead donors within 6 h before organ procurement between March 2015 and November 2016. We also analyzed the relationship between graft liver function and early graft survival after liver transplantation (LT). Results: Our results suggest that the ICG retention rate at 15 min (ICGR15) of donors before procurement was independently associated with 3-month graft survival after LT. The best donor ICGR15 cutoff value was 11.0%/min, and we observed a significant increase in 3-month graft failure among patients with a donor ICGR15 above this value. On the other hand, a donor ICGR15 value of ≤ 11.0%/min could be used as an early assessment index of graft quality because it provides additional information to the transplant surgeon or organ procurement organization members who must maintain or improve organ function to adapt the LT. Conclusion: An ICG clearance test before liver procurement might be an effective quantitative method to predict graft availability and improve early graft prognosis after LT.
KW - Graft quality
KW - Indocyanine green clearance test
KW - Liver transplantation
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U2 - 10.1007/s10620-017-4765-x
DO - 10.1007/s10620-017-4765-x
M3 - Article
C2 - 28932926
AN - SCOPUS:85029580149
SN - 0163-2116
VL - 62
SP - 3212
EP - 3220
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 11
ER -