Abstract
Background: Dolichocolon (DC) is an underrecognized anatomic variant associated with constipation; its association with ulcerative colitis (UC) is unknown. Methods: We retrospectively reviewed abdominal MRI and CT scans in children with UC, Crohn’s disease (CD), and non-inflammatory bowel disease (non-IBD) controls, classifying DC subtypes. Results: A total of 111 cases (66 with UC) were examined. DC was similarly common (p = 0.4436) in patients with constipated (69%) or non-constipated (NC-UC: 57%) UC. In non-constipated (NC) patients, DC prevalence was higher in children with UC than those with CD or controls. Type 1 DC predominated in NC children with proctitis/left-sided UC (E1/E2), while Type 2 DC was enriched in children with extensive/pancolitis (E3/E4). Discussion: DC may be associated with different phenotypes of UC and may influence disease distribution independent of constipation. However, given the cross-sectional design of this study, these associations should be interpreted cautiously and require confirmation in longitudinal studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5122-5126 |
| Number of pages | 5 |
| Journal | Digestive Diseases and Sciences |
| Volume | 71 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2026 |
Keywords
- Children
- Constipation
- Inflammatory bowel disease
- Phenotype modifier
- Redundant colon
- Humans
- Child, Preschool
- Male
- Tomography, X-Ray Computed
- Colitis, Ulcerative/diagnostic imaging
- Magnetic Resonance Imaging
- Phenotype
- Adolescent
- Female
- Retrospective Studies
- Child
- Constipation/etiology
- Crohn Disease/diagnostic imaging
ASJC Scopus subject areas
- Physiology
- Gastroenterology
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