@article{4322fbfb62014007ad6b26d88aeedeb4,
title = "Does occupational exposure to formaldehyde cause hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells?",
abstract = "Several cross-sectional studies of a single population of workers exposed to formaldehyde at one of two factories using or producing formaldehyde–melamine resins in China have concluded that formaldehyde exposure induces damage to hematopoietic cells that originate in the bone marrow. Moreover, the investigators interpret observed differences between groups as evidence that formaldehyde induces myeloid leukemias, although the mechanisms for inducing these diseases are not obvious and recently published scientific findings do not support causation. Our objective was to evaluate hematological parameters and aneuploidy in relation to quantitative exposure measures of formaldehyde. We obtained the study data for the original study (Zhang et al. 2010) and performed linear regression analyses. Results showed that differences in white blood cell, granulocyte, platelet, and red blood cell counts are not exposure dependent. Among formaldehyde-exposed workers, no association was observed between individual average formaldehyde exposure estimates and frequency of aneuploidy, suggested by the original study authors to be indicators of myeloid leukemia risk.",
keywords = "Formaldehyde, acute myeloid leukemia, hematopoietic cells, leukemia, myeloid leukemia",
author = "Mundt, {Kenneth A.} and Gallagher, {Alexa E.} and Dell, {Linda D.} and Natelson, {Ethan A.} and Paolo Boffetta and Gentry, {P. Robinan}",
note = "Funding Information: The authors thank Ms. Virginia A. DeSeau of the NCI Technology Transfer Center for her kind assistance in overseeing the data transfer agreement and Dr. Nathaniel Rothman (NCI) for locating and sending the data. We acknowledge comments offered for our consideration but with no obligation by Dr. Anne Jurek (The Dow Chemical Company) and Prof. Heinz-Peter Gelbke (BASF SE, Ludwigshafen am Rhein) on behalf of the study sponsors in response to a courtesy copy of the manuscript. We are especially grateful to Dr Michael Thirman (The University of Chicago Medicine) for his assistance in interpreting haematological findings, and for his review of and comments on our final manuscript. The authors also gratefully acknowledge the insightful and helpful comments provided by two anonymous peer-reviewers selected by the Editor, as well as the Editor. The final manuscript reflects revisions responsive to these questions and comments, resulting in a stronger and more transparent communication. This project was supported by funding provided by the Foundation for Chemistry Research and Initiatives (FCRI), formerly the Research Foundation for Health and Environmental Effects (RFHEE), a 501(c)(3) tax-exempt organization established by the American Chemistry Council (ACC). According to the description filed on Form 990 with the US Department of The Treasury, Internal Revenue Service, this organization is described as follows: “Established in 1995, RFHEE works to address uncertainties and answer questions on health and environmental issues related to the production and use of chlorine chemistry in the conduct of its business, RFHEE works with industry, public agencies, academia and other foundations on projects that will furnish crucial information, peer-reviewed scientific research, expert panels, and workshops that will provide information for public policy”.The sponsor had no role in study design, data analysis, decision to publish, or preparation of any manuscript. However, a courtesy copy of the final manuscript was provided to the sponsor prior to submission to CRT. Comments were received in response by Dr. Jurek and Prof. Gelbke as acknowledged above. The purpose of such review was to allow input on the clarity of the science presented but not in the interpretation of any of the research findings. No comments were provided relevant to the analyses, interpretations and conclusions presented in this manuscript, and the authors had no obligation to address or incorporate any comments provided by these colleagues. The authors{\textquoteright} scientific conclusions and professional judgments were exclusively those of the authors and were not subject to the sponsor{\textquoteright}s or any other potential source of influence or control. Therefore, the scientific conclusions and professional judgments may not represent the views of FCRI, ACC or the authors{\textquoteright} employers. Publisher Copyright: {\textcopyright} 2017 Ramboll Environ US Corporation. Published by Informa UK Limited, trading as Taylor & Francis Group.",
year = "2017",
month = aug,
day = "9",
doi = "10.1080/10408444.2017.1301878",
language = "English (US)",
volume = "47",
pages = "592--602",
journal = "Critical Reviews in Toxicology",
issn = "1040-8444",
publisher = "Informa Healthcare",
number = "7",
}