@article{3bd81c0f0b5441a983700d42ff97e673,
title = "Does ischemia free liver procurement under normothermic perfusion benefit the outcome of liver transplantation?",
abstract = "BACKGROUND In contrast to conventional static cold preservation, normothermic machine perfusion (NMP) provides a beneficial alternative preservation of donor livers. However, the liver still suffered cold ischemic injury before attaching to the perfusion device. MATERIAL AND METHODS To prevent cold ischemic injury during procurement, we describe a novel procedure called ischemia-free liver procurement (IFLP) under NMP. Two liver grafts were procured from brain death donor under NMP and underwent 2-hour ex vivo NMP followed by 3 and 6 hours of static cold preservation. From procurement to post-transplantation course, evidence was collected to prove that IFLP is safe and benefits recipients. RESULTS The post-transplantation course was uneventful, and the liver function tests and histological study revealed minimal hepatocyte and biliary epithelium injury during the preservation. CONCLUSIONS This preliminary experience demonstrates the clinical feasibility and safety of IFLP under NMP which offering opportunities to increase the number of donor livers and to improve the organ function.",
keywords = "Liver transplantation, Organ preservation, Tissue and organ procurement, Liver Function Tests, Temperature, Tissue and Organ Harvesting/instrumentation, Tissue and Organ Procurement/methods, Humans, Middle Aged, Male, Treatment Outcome, Perfusion/instrumentation, Feasibility Studies, Organ Preservation/methods, Reperfusion Injury/pathology, Liver Cirrhosis/surgery, Adult, Female, Safety, Liver Transplantation/methods",
author = "Qiang Zhao and Shanzhou Huang and Dongping Wang and Zhiheng Zhang and Linwei Wu and Lu Yang and Yi Ma and Fei Ji and Yunhua Tang and Linhe Wang and Zebin Zhu and Yanling Zhu and Wei Xiong and Maogen Chen and Ming Han and Jian Zhou and Anbin Hu and Guodong Wang and Xingyuan Jiao and Xiaofeng Zhu and Ju, {Wei Qiang} and Guo, {Zhi Yong} and He, {Xiao Shun}",
note = "Funding Information: * The first 3 authors contributed equally to this work and should be considered as co-first authors Xiao-Shun He, e-mail:
[email protected], Zhi-Yong Guo, e-mail:
[email protected], Wei-qiang Ju, e-mail:
[email protected] This study was supported by the National Natural Science Foundation of China (81373156 and 81471583), the Special Fund for Science Research by Ministry of Health (201302009), the Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People{\textquoteright}s Republic of China, the Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology (2013A061401007), Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation) (2015B050501002), Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project (2015A030308010), Guangdong Provincial Natural Science Funds for Distinguished Young Scholars (2015A030306025), Guangdong Provincial Natural Science Funds (2016A030310141), Special support program for training high level talents in Guangdong Province (2015TQ01R168), and Pearl River Nova Program of Guangzhou (201506010014) Publisher Copyright: {\textcopyright} Ann Transplant.",
year = "2018",
month = apr,
day = "20",
doi = "10.12659/AOT.909645",
language = "English (US)",
volume = "23",
pages = "258--267",
journal = "Annals of Transplantation",
issn = "1425-9524",
publisher = "International Scientific Information, Inc.",
}