Does ischemia free liver procurement under normothermic perfusion benefit the outcome of liver transplantation?

Qiang Zhao, Shanzhou Huang, Dongping Wang, Zhiheng Zhang, Linwei Wu, Lu Yang, Yi Ma, Fei Ji, Yunhua Tang, Linhe Wang, Zebin Zhu, Yanling Zhu, Wei Xiong, Maogen Chen, Ming Han, Jian Zhou, Anbin Hu, Guodong Wang, Xingyuan Jiao, Xiaofeng ZhuWei Qiang Ju, Zhi Yong Guo, Xiao Shun He

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: In contrast to conventional static cold preservation, normothermic machine perfusion (NMP) provides a beneficial alternative preservation of donor livers. However, the liver still suffered cold ischemic injury before attaching to the perfusion device. Material/Methods: To prevent cold ischemic injury during procurement, we describe a novel procedure called ischemia-free liver procurement (IFLP) under NMP. Two liver grafts were procured from brain death donor under NMP and underwent 2-hour ex vivo NMP followed by 3 and 6 hours of static cold preservation. From procurement to posttransplantation course, evidence was collected to prove that IFLP is safe and benefits recipients. Results: The post-transplantation course was uneventful, and the liver function tests and histological study revealed minimal hepatocyte and biliary epithelium injury during the preservation. Conclusions: This preliminary experience demonstrates the clinical feasibility and safety of IFLP under NMP which offering opportunities to increase the number of donor livers and to improve the organ function.

Original languageEnglish (US)
Pages (from-to)258-267
Number of pages10
JournalAnnals of Transplantation
Volume23
DOIs
StatePublished - Apr 20 2018

Keywords

  • Liver transplantation
  • Organ preservation
  • Tissue and organ procurement

ASJC Scopus subject areas

  • Transplantation

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