Does ischemia free liver procurement under normothermic perfusion benefit the outcome of liver transplantation?

Qiang Zhao, Shanzhou Huang, Dongping Wang, Zhiheng Zhang, Linwei Wu, Lu Yang, Yi Ma, Fei Ji, Yunhua Tang, Linhe Wang, Zebin Zhu, Yanling Zhu, Wei Xiong, Maogen Chen, Ming Han, Jian Zhou, Anbin Hu, Guodong Wang, Xingyuan Jiao, Xiaofeng ZhuWei Qiang Ju, Zhi Yong Guo, Xiao Shun He

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


BACKGROUND In contrast to conventional static cold preservation, normothermic machine perfusion (NMP) provides a beneficial alternative preservation of donor livers. However, the liver still suffered cold ischemic injury before attaching to the perfusion device. MATERIAL AND METHODS To prevent cold ischemic injury during procurement, we describe a novel procedure called ischemia-free liver procurement (IFLP) under NMP. Two liver grafts were procured from brain death donor under NMP and underwent 2-hour ex vivo NMP followed by 3 and 6 hours of static cold preservation. From procurement to post-transplantation course, evidence was collected to prove that IFLP is safe and benefits recipients. RESULTS The post-transplantation course was uneventful, and the liver function tests and histological study revealed minimal hepatocyte and biliary epithelium injury during the preservation. CONCLUSIONS This preliminary experience demonstrates the clinical feasibility and safety of IFLP under NMP which offering opportunities to increase the number of donor livers and to improve the organ function.

Original languageEnglish (US)
Pages (from-to)258-267
Number of pages10
JournalAnnals of Transplantation
StatePublished - Apr 20 2018


  • Liver transplantation
  • Organ preservation
  • Tissue and organ procurement
  • Liver Function Tests
  • Temperature
  • Tissue and Organ Harvesting/instrumentation
  • Tissue and Organ Procurement/methods
  • Humans
  • Middle Aged
  • Male
  • Treatment Outcome
  • Perfusion/instrumentation
  • Feasibility Studies
  • Organ Preservation/methods
  • Reperfusion Injury/pathology
  • Liver Cirrhosis/surgery
  • Adult
  • Female
  • Safety
  • Liver Transplantation/methods

ASJC Scopus subject areas

  • Medicine(all)


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