TY - JOUR
T1 - Does body fatness modify the association between dietary cholesterol and risk of coronary death? Results from the Chicago Western Electric Study
AU - Goff, D. C.
AU - Shekelle, R. B.
AU - Katan, M. B.
AU - Gotto, A. M.
AU - Stamler, J.
PY - 1992
Y1 - 1992
N2 - The hypothesis that body fatness modifies the relation between dietary cholesterol and 25-year coronary mortality was examined in a cohort of 1,792 middle-aged men employed by the Western Electric Company in Chicago. Relative risks of coronary death (and 95% confidence intervals) associated with a 225 mg/day greater intake of dietary cholesterol for men with a subscapular skinfold thickness ≤14, 15-20, and ≥21 mm were 1.44 (1.10-1.90), 1.07 (0.84-136), and 0.95 (0.76-1.20), respectively, after adjustment for age; serum total cholesterol level; systolic blood pressure; cigarette smoking; family history of cardiovascular disease; evidence of major organ system disease at baseline; and intake of saturated fatty acids, polyunsaturated fatty acids, energy, and ethanol. Adjusted relative risks associated with a 15-mm greater subscapular skinfold thickness for men with a dietary cholesterol intake ≤649, 650-799, and ≥800 mg/day were 1.76 (1.04-2.98), 1.64 (1.04-2.57), and 1.00 (0.69-1.55), respectively. Fatter men apparently did not benefit from a diet lower in cholesterol, while men who ate a diet high in cholesterol apparently did not benefit from leanness. These results support the hypothesis that body fatness modifies the relation between dietary cholesterol and coronary mortality, perhaps because leaner men are more responsive than fatter men to the effects of dietary cholesterol on the concentration of low density lipoprotein cholesterol. (Arteriosclerosis and Thrombosis 1992;12:755-761).
AB - The hypothesis that body fatness modifies the relation between dietary cholesterol and 25-year coronary mortality was examined in a cohort of 1,792 middle-aged men employed by the Western Electric Company in Chicago. Relative risks of coronary death (and 95% confidence intervals) associated with a 225 mg/day greater intake of dietary cholesterol for men with a subscapular skinfold thickness ≤14, 15-20, and ≥21 mm were 1.44 (1.10-1.90), 1.07 (0.84-136), and 0.95 (0.76-1.20), respectively, after adjustment for age; serum total cholesterol level; systolic blood pressure; cigarette smoking; family history of cardiovascular disease; evidence of major organ system disease at baseline; and intake of saturated fatty acids, polyunsaturated fatty acids, energy, and ethanol. Adjusted relative risks associated with a 15-mm greater subscapular skinfold thickness for men with a dietary cholesterol intake ≤649, 650-799, and ≥800 mg/day were 1.76 (1.04-2.98), 1.64 (1.04-2.57), and 1.00 (0.69-1.55), respectively. Fatter men apparently did not benefit from a diet lower in cholesterol, while men who ate a diet high in cholesterol apparently did not benefit from leanness. These results support the hypothesis that body fatness modifies the relation between dietary cholesterol and coronary mortality, perhaps because leaner men are more responsive than fatter men to the effects of dietary cholesterol on the concentration of low density lipoprotein cholesterol. (Arteriosclerosis and Thrombosis 1992;12:755-761).
KW - Body fatness
KW - Coronary heart disease
KW - Dietary cholesterol
KW - Mortality
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U2 - 10.1161/01.atv.12.7.755
DO - 10.1161/01.atv.12.7.755
M3 - Article
C2 - 1616901
AN - SCOPUS:0026694742
VL - 12
SP - 755
EP - 761
JO - Arteriosclerosis and Thrombosis
JF - Arteriosclerosis and Thrombosis
SN - 1049-8834
IS - 7
ER -