TY - JOUR
T1 - Does apolipoprotein E genotype modify the clinical expression of ALS?
AU - Jawaid, A.
AU - Poon, M.
AU - Strutt, A. M.
AU - Rice, L. K.
AU - Mcdowell, E. J.
AU - Salamone, A. R.
AU - Qureshi, S. U.
AU - Greene, Ericka P.
AU - Appel, Stanley H.
AU - York, M. K.
AU - Schulz, P. E.
PY - 2011/4
Y1 - 2011/4
N2 - Background: The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (ALS). Methods: Eight hundred and fifty-two consecutive patients with sporadic ALS evaluated at a tertiary care center were investigated for the effect of ApoE genotype on age of onset, rate of motor disease progression, cognitive functioning, and survival in ALS. Results: The frequencies of individual ApoE genotypes did not differ between patients with ALS and ALS-free Caucasian populations. Patients with different ApoE genotypes did not differ in the age of onset for ALS (years) (ApoE2=57.8±13.7, ApoE3=57.3±13.7, ApoE4=57.7±13.2; P=0.97), the rate of disease progression (Appel ALS score/month) (ApoE2=2.91±2.66, ApoE3=2.67±2.66, ApoE4=2.61±2.47; P=0.89), cognitive status (% cognitively impaired) (ApoE2=31.7, ApoE3=26.8, ApoE4=34.3, P=0.28), or survival in years (ApoE2=3.79±3.70, ApoE3=3.17±2.27, ApoE4=3.05±1.75; P=0.85). Conclusions: Our results suggest that ApoE genotype does not modify clinical course of sporadic ALS, in stark contrast to the influence of ApoE genotype on the disease course of AD and other neurodegenerative disorders.
AB - Background: The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (ALS). Methods: Eight hundred and fifty-two consecutive patients with sporadic ALS evaluated at a tertiary care center were investigated for the effect of ApoE genotype on age of onset, rate of motor disease progression, cognitive functioning, and survival in ALS. Results: The frequencies of individual ApoE genotypes did not differ between patients with ALS and ALS-free Caucasian populations. Patients with different ApoE genotypes did not differ in the age of onset for ALS (years) (ApoE2=57.8±13.7, ApoE3=57.3±13.7, ApoE4=57.7±13.2; P=0.97), the rate of disease progression (Appel ALS score/month) (ApoE2=2.91±2.66, ApoE3=2.67±2.66, ApoE4=2.61±2.47; P=0.89), cognitive status (% cognitively impaired) (ApoE2=31.7, ApoE3=26.8, ApoE4=34.3, P=0.28), or survival in years (ApoE2=3.79±3.70, ApoE3=3.17±2.27, ApoE4=3.05±1.75; P=0.85). Conclusions: Our results suggest that ApoE genotype does not modify clinical course of sporadic ALS, in stark contrast to the influence of ApoE genotype on the disease course of AD and other neurodegenerative disorders.
KW - Cohort study
KW - Motor neuron disease
KW - Neurological disorders
KW - Neuromuscular diseases
KW - Research methods
UR - http://www.scopus.com/inward/record.url?scp=79952725883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952725883&partnerID=8YFLogxK
U2 - 10.1111/j.1468-1331.2010.03225.x
DO - 10.1111/j.1468-1331.2010.03225.x
M3 - Article
C2 - 20880000
AN - SCOPUS:79952725883
SN - 1351-5101
VL - 18
SP - 618
EP - 624
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 4
ER -