Abstract
Objectives: Gallbladder carcinoma (GBC) is highly aggressive neoplasm which arises in the background of gall stones and inflammation. GBC affects women 2-3 times more frequently than men. Pro-inflammatory TNFA and IL6 gene polymorphism has been associated with various inflammatory diseases. The aim of this study was to investigate whether TNFA-308 (G/A) and IL6-174 G/C polymorphisms within flanking region of the genes are associated with GBC susceptibility. Methods: The promoter polymorphisms were genotyped using PCRRFLP in 200 healthy subjects and 124 GBC patients. Results: Frequency distribution of TNFA-308 (G/A) and IL6-174 G/C were not significantly different in GBC patients in comparison to healthy controls. However, frequency of TNFA-308 (G/A) polymorphism in female GBC patients without gallstone were significantly different (p-value= 0.006) when compared to healthy female subjects (OR=3.054; 95% CI=1.39-6.72). Conclusion: These results suggest that TNFA-308 (G/A) polymorphism may influence the susceptibility of female gender gallbladder cancer in absence of gallstones while IL6-174 G/C polymorphism does not seem to be playing significant role in the susceptibility to gallbladder cancer.
Original language | English (US) |
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Pages (from-to) | 567-572 |
Number of pages | 6 |
Journal | Asian Pacific Journal of Cancer Prevention |
Volume | 8 |
Issue number | 4 |
State | Published - 2007 |
Keywords
- Gallbladder carcinoma
- Gallstones
- Genetic susceptibility
- Il6
- Inflammation
- Polymorphism
- TNFA
ASJC Scopus subject areas
- Epidemiology
- Oncology
- Public Health, Environmental and Occupational Health
- Cancer Research