TY - JOUR
T1 - 'Do I like this person?' A network analysis of midline cortex during a social preference task
AU - Chen, Ashley C.
AU - Welsh, Robert C.
AU - Liberzon, Israel
AU - Taylor, Stephan F.
N1 - Funding Information:
The study was supported by the National Institute of Mental Health ( R01 MH01258 to SFT). We thank Wendy Davis for subject recruitment and Keith Newnham for data acquisition.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/6
Y1 - 2010/6
N2 - Human communication and survival depend on effective social information processing. Abundant behavioral evidence has shown that humans efficiently judge preferences for other individuals, a critical task in social interaction, yet the neural mechanism of this basic social evaluation, remains less than clear. Using a socio-emotional preference task and connectivity analyses (psycho-physiological interaction) of fMRI data, we first demonstrated that cortical midline structures (medial prefrontal and posterior cingulate cortices) and the task-positive network typically implicated in carrying out goal-directed tasks (pre-supplementary motor area, dorsal anterior cingulate and bilateral frontoparietal cortices) were both recruited when subjects made a preference judgment, relative to gender identification, to human faces. Connectivity analyses further showed network interactions among these cortical midline structures, and with the task-positive network, both of which vary as a function of social preference. Overall, the data demonstrate the involvement of cortical midline structures in forming social preference, and provide evidence of network interactions which might reflect a mechanism by which an individual regularly forms and expresses this fundamental decision.
AB - Human communication and survival depend on effective social information processing. Abundant behavioral evidence has shown that humans efficiently judge preferences for other individuals, a critical task in social interaction, yet the neural mechanism of this basic social evaluation, remains less than clear. Using a socio-emotional preference task and connectivity analyses (psycho-physiological interaction) of fMRI data, we first demonstrated that cortical midline structures (medial prefrontal and posterior cingulate cortices) and the task-positive network typically implicated in carrying out goal-directed tasks (pre-supplementary motor area, dorsal anterior cingulate and bilateral frontoparietal cortices) were both recruited when subjects made a preference judgment, relative to gender identification, to human faces. Connectivity analyses further showed network interactions among these cortical midline structures, and with the task-positive network, both of which vary as a function of social preference. Overall, the data demonstrate the involvement of cortical midline structures in forming social preference, and provide evidence of network interactions which might reflect a mechanism by which an individual regularly forms and expresses this fundamental decision.
KW - Cortical midline structures
KW - FMRI BOLD
KW - Functional connectivity
KW - Psycho-physiological interaction
KW - Social cognition
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U2 - 10.1016/j.neuroimage.2010.02.044
DO - 10.1016/j.neuroimage.2010.02.044
M3 - Article
C2 - 20188190
AN - SCOPUS:77951976026
VL - 51
SP - 930
EP - 939
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 2
ER -