DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond

Joel N. Maslow; Ijoo Kwon; Sagar B. Kudchodkar; Deborah Kane; Amha Tadesse; Hyojin Lee; Young K. Park; Kar Muthumani; Christine C. Roberts

doi:10.3390/vaccines11061016

DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond

Joel N. Maslow, Ijoo Kwon, Sagar B. Kudchodkar, Deborah Kane, Amha Tadesse, Hyojin Lee, Young K. Park, Kar Muthumani, Christine C. Roberts

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received authorization for use. DNA vaccines have significant advantages with regard to the rapidity of production, thermostability, safety profile, and cellular immune responses. Based on user needs and cost, we compare the three devices used in the SARS-CoV-2 clinical trials. Of the three devices, the GeneDerm suction device offers numerous benefits, particularly for international vaccination campaigns. As such, DNA vaccines represent a promising option for future pandemics.

Original language	English (US)
Article number	1016
Journal	Vaccines
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/vaccines11061016
State	Published - May 23 2023

Keywords

DNA vaccine
SARS-CoV-2
suction-mediated DNA transfection
vaccine thermostability

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

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10.3390/vaccines11061016

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title = "DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond",

abstract = "We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received authorization for use. DNA vaccines have significant advantages with regard to the rapidity of production, thermostability, safety profile, and cellular immune responses. Based on user needs and cost, we compare the three devices used in the SARS-CoV-2 clinical trials. Of the three devices, the GeneDerm suction device offers numerous benefits, particularly for international vaccination campaigns. As such, DNA vaccines represent a promising option for future pandemics.",

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doi = "10.3390/vaccines11061016",

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AU - Maslow, Joel N.

AU - Kwon, Ijoo

AU - Kudchodkar, Sagar B.

AU - Kane, Deborah

AU - Tadesse, Amha

AU - Lee, Hyojin

AU - Park, Young K.

AU - Muthumani, Kar

AU - Roberts, Christine C.

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AB - We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received authorization for use. DNA vaccines have significant advantages with regard to the rapidity of production, thermostability, safety profile, and cellular immune responses. Based on user needs and cost, we compare the three devices used in the SARS-CoV-2 clinical trials. Of the three devices, the GeneDerm suction device offers numerous benefits, particularly for international vaccination campaigns. As such, DNA vaccines represent a promising option for future pandemics.

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DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond

Abstract

Keywords

ASJC Scopus subject areas

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