DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)n·(AGAAT)n Repeats Suggest a DNA Amplification Model for Repeat Expansion

Vladimir N. Potaman; Malgorzata J. Pytlos; Vera I. Hashem; John J. Bissler; Michael Leffak; Richard R. Sinden

doi:10.1016/B978-012369462-1/50031-4

DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion

Vladimir N. Potaman, Malgorzata J. Pytlos, Vera I. Hashem, John J. Bissler, Michael Leffak, Richard R. Sinden

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

This chapter discusses DNA structure and genetic instabilities associated with on spinocerebellar ataxia type 10 (ATTCT)_n ·(AGAA TTCT)_n·(AGAA TTCT)_n ·(AGAA TTCT)_n ·(AGAAT)_n repeats undergo expansion associated with a complex mutational event upon prolonged growth in E. coli. The complex mutations involved both plasmid dimerization and inversion of a part of the repeat tract forms an inverted repeat. The results are consistent with a high frequency of primer-template misalignment during DNA replication.

Original language	English (US)
Title of host publication	Genetic Instabilities and Neurological Diseases
Publisher	Elsevier
Pages	447-460
Number of pages	14
ISBN (Print)	9780123694621
DOIs	https://doi.org/10.1016/B978-012369462-1/50031-4
State	Published - Jul 11 2006

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-012369462-1/50031-4

Cite this

Potaman, V. N., Pytlos, M. J., Hashem, V. I., Bissler, J. J., Leffak, M., & Sinden, R. R. (2006). DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion. In Genetic Instabilities and Neurological Diseases (pp. 447-460). Elsevier. https://doi.org/10.1016/B978-012369462-1/50031-4

DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion. / Potaman, Vladimir N.; Pytlos, Malgorzata J.; Hashem, Vera I. et al.
Genetic Instabilities and Neurological Diseases. Elsevier, 2006. p. 447-460.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Potaman, VN, Pytlos, MJ, Hashem, VI, Bissler, JJ, Leffak, M & Sinden, RR 2006, DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion. in Genetic Instabilities and Neurological Diseases. Elsevier, pp. 447-460. https://doi.org/10.1016/B978-012369462-1/50031-4

@inbook{1ba224a1f86e42b69d1dea0c61b52284,

title = "DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)n·(AGAAT)n Repeats Suggest a DNA Amplification Model for Repeat Expansion",

abstract = "This chapter discusses DNA structure and genetic instabilities associated with on spinocerebellar ataxia type 10 (ATTCT)n ·(AGAA TTCT)n·(AGAA TTCT)n ·(AGAA TTCT)n ·(AGAAT)n repeats undergo expansion associated with a complex mutational event upon prolonged growth in E. coli. The complex mutations involved both plasmid dimerization and inversion of a part of the repeat tract forms an inverted repeat. The results are consistent with a high frequency of primer-template misalignment during DNA replication.",

author = "Potaman, \{Vladimir N.\} and Pytlos, \{Malgorzata J.\} and Hashem, \{Vera I.\} and Bissler, \{John J.\} and Michael Leffak and Sinden, \{Richard R.\}",

year = "2006",

month = jul,

day = "11",

doi = "10.1016/B978-012369462-1/50031-4",

language = "English (US)",

isbn = "9780123694621",

pages = "447--460",

booktitle = "Genetic Instabilities and Neurological Diseases",

publisher = "Elsevier",

address = "United States",

}

TY - CHAP

T1 - DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)n·(AGAAT)n Repeats Suggest a DNA Amplification Model for Repeat Expansion

AU - Potaman, Vladimir N.

AU - Pytlos, Malgorzata J.

AU - Hashem, Vera I.

AU - Bissler, John J.

AU - Leffak, Michael

AU - Sinden, Richard R.

PY - 2006/7/11

Y1 - 2006/7/11

N2 - This chapter discusses DNA structure and genetic instabilities associated with on spinocerebellar ataxia type 10 (ATTCT)n ·(AGAA TTCT)n·(AGAA TTCT)n ·(AGAA TTCT)n ·(AGAAT)n repeats undergo expansion associated with a complex mutational event upon prolonged growth in E. coli. The complex mutations involved both plasmid dimerization and inversion of a part of the repeat tract forms an inverted repeat. The results are consistent with a high frequency of primer-template misalignment during DNA replication.

AB - This chapter discusses DNA structure and genetic instabilities associated with on spinocerebellar ataxia type 10 (ATTCT)n ·(AGAA TTCT)n·(AGAA TTCT)n ·(AGAA TTCT)n ·(AGAAT)n repeats undergo expansion associated with a complex mutational event upon prolonged growth in E. coli. The complex mutations involved both plasmid dimerization and inversion of a part of the repeat tract forms an inverted repeat. The results are consistent with a high frequency of primer-template misalignment during DNA replication.

UR - https://www.scopus.com/pages/publications/84882468921

UR - https://www.scopus.com/inward/citedby.url?scp=84882468921&partnerID=8YFLogxK

U2 - 10.1016/B978-012369462-1/50031-4

DO - 10.1016/B978-012369462-1/50031-4

M3 - Chapter

AN - SCOPUS:84882468921

SN - 9780123694621

SP - 447

EP - 460

BT - Genetic Instabilities and Neurological Diseases

PB - Elsevier

ER -

DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this