DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)n·(AGAAT)n Repeats Suggest a DNA Amplification Model for Repeat Expansion

Vladimir N. Potaman; Malgorzata J. Pytlos; Vera I. Hashem; John J. Bissler; Michael Leffak; Richard R. Sinden

doi:10.1016/B978-012369462-1/50031-4

DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion

Vladimir N. Potaman, Malgorzata J. Pytlos, Vera I. Hashem, John J. Bissler, Michael Leffak, Richard R. Sinden

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

This chapter discusses DNA structure and genetic instabilities associated with on spinocerebellar ataxia type 10 (ATTCT)_n ·(AGAA TTCT)_n·(AGAA TTCT)_n ·(AGAA TTCT)_n ·(AGAAT)_n repeats undergo expansion associated with a complex mutational event upon prolonged growth in E. coli. The complex mutations involved both plasmid dimerization and inversion of a part of the repeat tract forms an inverted repeat. The results are consistent with a high frequency of primer-template misalignment during DNA replication.

Original language	English (US)
Title of host publication	Genetic Instabilities and Neurological Diseases
Publisher	Elsevier
Pages	447-460
Number of pages	14
ISBN (Print)	9780123694621
DOIs	https://doi.org/10.1016/B978-012369462-1/50031-4
State	Published - Jul 11 2006

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-012369462-1/50031-4

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Potaman, V. N., Pytlos, M. J., Hashem, V. I., Bissler, J. J., Leffak, M., & Sinden, R. R. (2006). DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion. In Genetic Instabilities and Neurological Diseases (pp. 447-460). Elsevier. https://doi.org/10.1016/B978-012369462-1/50031-4

DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion. / Potaman, Vladimir N.; Pytlos, Malgorzata J.; Hashem, Vera I. et al.

Genetic Instabilities and Neurological Diseases. Elsevier, 2006. p. 447-460.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Potaman, VN, Pytlos, MJ, Hashem, VI, Bissler, JJ, Leffak, M & Sinden, RR 2006, DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion. in Genetic Instabilities and Neurological Diseases. Elsevier, pp. 447-460. https://doi.org/10.1016/B978-012369462-1/50031-4

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DNA Structures and Genetic Instabilities Associated with Spinocerebellar Ataxia type 10 (ATTCT)_n·(AGAAT)_n Repeats Suggest a DNA Amplification Model for Repeat Expansion

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