This chapter discusses DNA structure and genetic instabilities associated with on spinocerebellar ataxia type 10 (ATTCT)n ·(AGAA TTCT)n·(AGAA TTCT)n ·(AGAA TTCT)n ·(AGAAT)n repeats undergo expansion associated with a complex mutational event upon prolonged growth in E. coli. The complex mutations involved both plasmid dimerization and inversion of a part of the repeat tract forms an inverted repeat. The results are consistent with a high frequency of primer-template misalignment during DNA replication.
|Original language||English (US)|
|Title of host publication||Genetic Instabilities and Neurological Diseases|
|Number of pages||14|
|State||Published - Jul 11 2006|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)