DNA Modifications and Neurological Disorders

Research output: Contribution to journalReview article

Yi Lan Weng, Ran An, Jaehoon Shin, Hongjun Song, Guo li Ming

Mounting evidence has recently underscored the importance of DNA methylation in normal brain functions. DNA methylation machineries are responsible for dynamic regulation of methylation patterns in discrete brain regions. In addition to methylation of cytosines in genomic DNA (5-methylcytosine; 5mC), other forms of modified cytosines, such as 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, can potentially act as epigenetic marks that regulate gene expression. Importantly, epigenetic modifications require cognate binding proteins to read and translate information into gene expression regulation. Abnormal or incorrect interpretation of DNA methylation patterns can cause devastating consequences, including mental illnesses and neurological disorders. Although DNA methylation was generally considered to be a stable epigenetic mark in post-mitotic cells, recent studies have revealed dynamic DNA modifications in neurons. Such reversibility of 5mC sheds light on potential mechanisms underlying some neurological disorders and suggests a new route to correct aberrant methylation patterns associated with these disorders.

Original languageEnglish (US)
Pages (from-to)556-567
Number of pages12
JournalNeurotherapeutics
Volume10
Issue number4
DOIs
StatePublished - Oct 1 2013

PMID: 24150811

PMCID: PMC3805853

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DNA Modifications and Neurological Disorders. / Weng, Yi Lan; An, Ran; Shin, Jaehoon; Song, Hongjun; Ming, Guo li.

In: Neurotherapeutics, Vol. 10, No. 4, 01.10.2013, p. 556-567.

Research output: Contribution to journalReview article

Harvard

Weng, YL, An, R, Shin, J, Song, H & Ming, GL 2013, 'DNA Modifications and Neurological Disorders' Neurotherapeutics, vol. 10, no. 4, pp. 556-567. https://doi.org/10.1007/s13311-013-0223-4

APA

Weng, Y. L., An, R., Shin, J., Song, H., & Ming, G. L. (2013). DNA Modifications and Neurological Disorders. Neurotherapeutics, 10(4), 556-567. https://doi.org/10.1007/s13311-013-0223-4

Vancouver

Weng YL, An R, Shin J, Song H, Ming GL. DNA Modifications and Neurological Disorders. Neurotherapeutics. 2013 Oct 1;10(4):556-567. https://doi.org/10.1007/s13311-013-0223-4

Author

Weng, Yi Lan ; An, Ran ; Shin, Jaehoon ; Song, Hongjun ; Ming, Guo li. / DNA Modifications and Neurological Disorders. In: Neurotherapeutics. 2013 ; Vol. 10, No. 4. pp. 556-567.

BibTeX

@article{0e66d74031964186bae1fa99d719567b,
title = "DNA Modifications and Neurological Disorders",
abstract = "Mounting evidence has recently underscored the importance of DNA methylation in normal brain functions. DNA methylation machineries are responsible for dynamic regulation of methylation patterns in discrete brain regions. In addition to methylation of cytosines in genomic DNA (5-methylcytosine; 5mC), other forms of modified cytosines, such as 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, can potentially act as epigenetic marks that regulate gene expression. Importantly, epigenetic modifications require cognate binding proteins to read and translate information into gene expression regulation. Abnormal or incorrect interpretation of DNA methylation patterns can cause devastating consequences, including mental illnesses and neurological disorders. Although DNA methylation was generally considered to be a stable epigenetic mark in post-mitotic cells, recent studies have revealed dynamic DNA modifications in neurons. Such reversibility of 5mC sheds light on potential mechanisms underlying some neurological disorders and suggests a new route to correct aberrant methylation patterns associated with these disorders.",
keywords = "5hmC, DNA demethylation, DNA methylation, DNMT, GADD45, TET",
author = "Weng, {Yi Lan} and Ran An and Jaehoon Shin and Hongjun Song and Ming, {Guo li}",
year = "2013",
month = "10",
day = "1",
doi = "10.1007/s13311-013-0223-4",
language = "English (US)",
volume = "10",
pages = "556--567",
journal = "Neurotherapeutics",
issn = "1933-7213",
publisher = "Springer New York",
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}

RIS

TY - JOUR

T1 - DNA Modifications and Neurological Disorders

AU - Weng, Yi Lan

AU - An, Ran

AU - Shin, Jaehoon

AU - Song, Hongjun

AU - Ming, Guo li

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Mounting evidence has recently underscored the importance of DNA methylation in normal brain functions. DNA methylation machineries are responsible for dynamic regulation of methylation patterns in discrete brain regions. In addition to methylation of cytosines in genomic DNA (5-methylcytosine; 5mC), other forms of modified cytosines, such as 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, can potentially act as epigenetic marks that regulate gene expression. Importantly, epigenetic modifications require cognate binding proteins to read and translate information into gene expression regulation. Abnormal or incorrect interpretation of DNA methylation patterns can cause devastating consequences, including mental illnesses and neurological disorders. Although DNA methylation was generally considered to be a stable epigenetic mark in post-mitotic cells, recent studies have revealed dynamic DNA modifications in neurons. Such reversibility of 5mC sheds light on potential mechanisms underlying some neurological disorders and suggests a new route to correct aberrant methylation patterns associated with these disorders.

AB - Mounting evidence has recently underscored the importance of DNA methylation in normal brain functions. DNA methylation machineries are responsible for dynamic regulation of methylation patterns in discrete brain regions. In addition to methylation of cytosines in genomic DNA (5-methylcytosine; 5mC), other forms of modified cytosines, such as 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, can potentially act as epigenetic marks that regulate gene expression. Importantly, epigenetic modifications require cognate binding proteins to read and translate information into gene expression regulation. Abnormal or incorrect interpretation of DNA methylation patterns can cause devastating consequences, including mental illnesses and neurological disorders. Although DNA methylation was generally considered to be a stable epigenetic mark in post-mitotic cells, recent studies have revealed dynamic DNA modifications in neurons. Such reversibility of 5mC sheds light on potential mechanisms underlying some neurological disorders and suggests a new route to correct aberrant methylation patterns associated with these disorders.

KW - 5hmC

KW - DNA demethylation

KW - DNA methylation

KW - DNMT

KW - GADD45

KW - TET

UR - http://www.scopus.com/inward/record.url?scp=84886284988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886284988&partnerID=8YFLogxK

U2 - 10.1007/s13311-013-0223-4

DO - 10.1007/s13311-013-0223-4

M3 - Review article

VL - 10

SP - 556

EP - 567

JO - Neurotherapeutics

T2 - Neurotherapeutics

JF - Neurotherapeutics

SN - 1933-7213

IS - 4

ER -

ID: 41876165