DNA manipulation, sorting, and mapping in nanofluidic systems

Stephen L. Levy, Harold G. Craighead

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules. Nanofluidic systems have been used to probe conformational, dynamic, and entropic properties of DNA molecules, to rapidly sort DNA molecules based on length dependent interactions with their confining environment, and for determining the spatial location of genetic information along long DNA molecules. In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references).

Original languageEnglish (US)
Pages (from-to)1133-1152
Number of pages20
JournalChemical Society Reviews
Volume39
Issue number3
DOIs
StatePublished - Feb 24 2010

ASJC Scopus subject areas

  • Chemistry(all)

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