TY - JOUR
T1 - DNA manipulation, sorting, and mapping in nanofluidic systems
AU - Levy, Stephen L.
AU - Craighead, Harold G.
PY - 2010/2/24
Y1 - 2010/2/24
N2 - Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules. Nanofluidic systems have been used to probe conformational, dynamic, and entropic properties of DNA molecules, to rapidly sort DNA molecules based on length dependent interactions with their confining environment, and for determining the spatial location of genetic information along long DNA molecules. In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references).
AB - Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules. Nanofluidic systems have been used to probe conformational, dynamic, and entropic properties of DNA molecules, to rapidly sort DNA molecules based on length dependent interactions with their confining environment, and for determining the spatial location of genetic information along long DNA molecules. In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references).
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U2 - 10.1039/b820266b
DO - 10.1039/b820266b
M3 - Article
C2 - 20179829
AN - SCOPUS:77952531418
SN - 0306-0012
VL - 39
SP - 1133
EP - 1152
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 3
ER -