DNA induced folding/fibrillation of alpha-synuclein: New insights in Parkinson's disease

Muralidhar L. Hegde, Padmaraju Vasudevaraju, Kosagisharaf Jagannatha Rao

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Emerging evidences on the nuclear localization of alpha-Synuclein in neurons and a close look in to its primary sequence/structural organization led us to examine its DNA binding ability. Subsequently, we first time demonstrated the interaction of DNA with alpha-Synuclein which was also confirmed by others. We recently showed that double-stranded oligos induce partial folding in alpha- Synuclein and promote its aggregation, where as singlestrand circular DNA and supercoiled plasmid DNA induced a helix-rich conformation and protected the protein from fibrillation. In turn, alpha-Synuclein modulates DNA conformation from B- to an altered B-form, which may affect DNA transactions. Interestingly, amyloid-beta peptides and prion proteins implicated in Alzheimer's disease and Prion diseases respectively, were also shown to have DNA binding activity which suggests that DNA binding may be a common property of many amyloidogenic proteins associated with various neurodegenerative disorders. In this review, we debate the biological significance of DNA-alpha-Synuclein interactions; it's beneficial vs. toxic role in relevance to Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)418-436
Number of pages19
JournalFrontiers in Bioscience
Volume15
Issue number2
DOIs
StatePublished - Jan 1 2010

Keywords

  • Alpha-Synuclein
  • Alpha-Synuclein conformation
  • Alpha-Synuclein-DNA interaction
  • Neurodegeneration
  • Parkinson's disease
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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