DNA content and proliferative activity of cystosarcoma phyllodes of the breast. Potential prognostic significance

A. K. El-Naggar, J. Y. Ro, D. McLemore, L. Garnsy

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Predicting the biologic behavior of cystosarcoma phyllodes of the breast by histopathologic examination has been difficult. Flow cytometric DNA and cell cycle analysis was performed for 30 patients with cystosarcoma phyllodes of the breast to determine its potential prognostic utility. Traditional histopathologic parameters and the patients' clinical outcome with a minimum follow-up period of at least five years were also analyzed. Of all the variables examined, DNA ploidy, proliferative index, number of mitoses, and tumor margin were significantly associated with an adverse clinical course. Multivariate regression analysis of the authors' data showed that DNA content was a significant predictor of the patients' clinical outcome. The authors conclude that the DNA ploidy study is a useful, objective adjunct to the clinicopathologic assessment of cytosarcoma phyllodes of the breast.

Original languageEnglish (US)
Pages (from-to)480-485
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume93
Issue number4
DOIs
StatePublished - 1990

Keywords

  • Breast
  • Cystosarcoma phyllodes
  • DNA ploidy
  • Proliferative index

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'DNA content and proliferative activity of cystosarcoma phyllodes of the breast. Potential prognostic significance'. Together they form a unique fingerprint.

Cite this