DNA-based identification and epidemiologic typing of bacterial pathogens

James Versalovic, C. R. Woods, P. R. Georghiou, R. J. Hamill, J. R. Lupski

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Genotypic, or DNA-based, methods have become increasingly applicable for infectious disease diagnosis and epidemiologic analysis. The ability to assess the pathogen's genotype directly bypasses requirements for cultivation and may diminish diagnostic delays with fastidious organisms. Genotypic typing methods have enhanced epidemiologic studies by providing techniques with greater discriminatory ability and smaller proportions of nontypeable samples. Hence, these methods enable rigorous studies to be performed regarding the nature of disease outbreaks. Phenotypic, or conventional, methods will remain important in diagnostic microbiology, especially with organisms that are relatively easy to culture. However, genotypic methods may become increasingly prominent in clinical microbiology laboratories, particularly with respect to diagnosis of fastidious pathogens, because of their relative speed, versatility, and lack of cultivation requirements.

Original languageEnglish (US)
Pages (from-to)1088-1098
Number of pages11
JournalArchives of Pathology and Laboratory Medicine
Volume117
Issue number11
StatePublished - 1993

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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