DNA-based detection of mercury(ii) ions through characteristic current signals in nanopores with high sensitivity and selectivity

Tao Zeng; Ting Li; Yuru Li; Lei Liu; Xingyong Wang; Quansheng Liu; Yuliang Zhao; Hai Chen Wu

doi:10.1039/c4nr02062f

DNA-based detection of mercury(ii) ions through characteristic current signals in nanopores with high sensitivity and selectivity

Tao Zeng, Ting Li, Yuru Li, Lei Liu, Xingyong Wang, Quansheng Liu, Yuliang Zhao, Hai Chen Wu

Houston Methodist

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We report single-molecule detection of Hg²⁺ by threading an Hg²⁺-mediated DNA duplex through α-hemolysin nanopores, which generates characteristic three-level current patterns and enables the unambiguous detection of Hg²⁺. This strategy precludes any background interference and features high sensitivity and selectivity. Moreover, the platform could be readily integrated with aptamers and molecular beacons, offering extended possibilities for the construction of a new DNA-based nanopore sensing system. This journal is

Original language	English (US)
Pages (from-to)	8579-8584
Number of pages	6
Journal	Nanoscale
Volume	6
Issue number	15
DOIs	https://doi.org/10.1039/c4nr02062f
State	Published - Aug 7 2014

ASJC Scopus subject areas

General Materials Science

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abstract = "We report single-molecule detection of Hg2+ by threading an Hg2+-mediated DNA duplex through α-hemolysin nanopores, which generates characteristic three-level current patterns and enables the unambiguous detection of Hg2+. This strategy precludes any background interference and features high sensitivity and selectivity. Moreover, the platform could be readily integrated with aptamers and molecular beacons, offering extended possibilities for the construction of a new DNA-based nanopore sensing system. This journal is",

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AU - Zeng, Tao

AU - Li, Ting

AU - Li, Yuru

AU - Liu, Lei

AU - Wang, Xingyong

AU - Liu, Quansheng

AU - Zhao, Yuliang

AU - Wu, Hai Chen

PY - 2014/8/7

Y1 - 2014/8/7

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AB - We report single-molecule detection of Hg2+ by threading an Hg2+-mediated DNA duplex through α-hemolysin nanopores, which generates characteristic three-level current patterns and enables the unambiguous detection of Hg2+. This strategy precludes any background interference and features high sensitivity and selectivity. Moreover, the platform could be readily integrated with aptamers and molecular beacons, offering extended possibilities for the construction of a new DNA-based nanopore sensing system. This journal is

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JO - Nanoscale

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DNA-based detection of mercury(ii) ions through characteristic current signals in nanopores with high sensitivity and selectivity

Abstract

ASJC Scopus subject areas

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