DNA-based detection of mercury(ii) ions through characteristic current signals in nanopores with high sensitivity and selectivity

Tao Zeng, Ting Li, Yuru Li, Lei Liu, Xingyong Wang, Quansheng Liu, Yuliang Zhao, Hai Chen Wu

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We report single-molecule detection of Hg2+ by threading an Hg2+-mediated DNA duplex through α-hemolysin nanopores, which generates characteristic three-level current patterns and enables the unambiguous detection of Hg2+. This strategy precludes any background interference and features high sensitivity and selectivity. Moreover, the platform could be readily integrated with aptamers and molecular beacons, offering extended possibilities for the construction of a new DNA-based nanopore sensing system. This journal is

Original languageEnglish (US)
Pages (from-to)8579-8584
Number of pages6
JournalNanoscale
Volume6
Issue number15
DOIs
StatePublished - Aug 7 2014

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'DNA-based detection of mercury(ii) ions through characteristic current signals in nanopores with high sensitivity and selectivity'. Together they form a unique fingerprint.

Cite this