TY - JOUR
T1 - Diurnal variations in excretion of corticosteroid metabolites in bile from male and female rats
AU - Begue, René Jean
AU - Gustafsson, Jan Åke
AU - Gustafsson, Sven A.
N1 - Funding Information:
ACKNOWLEDGEMENTS This investigationw as supportedb y a grant from the Swedish Medical ResearchC ouncil (13X-2819).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1973/7
Y1 - 1973/7
N2 - The excretion of corticosteroids in bile has been studied in female and male rats. The total daily excretion of corticosteroids in female rats was 738 ± 169 ms (3α,11β,15α,21-tetrahydroxy-5α-pregnan-20-one monosulphate: 300 ± 16 μg; 3α,11β,15α,21-tetrahydroxy-5α-pregnan-20-one disulphate: 158 ± 51 μg; 3α,11β,21-trihydroxy-5α-pregnan-20-one disulphate: 146 ± 49 μg; and 3β,11β,21-trihydroxy-5α-pregnan-20-one disulphate: 134 ± 38μg) and in male rats the corresponding figure was 773 ± 97 μg (3β,11β,21-trihydroxy-5α-pregnan-20-one disulphate: 682 ± 72 μg; and 5α-pregnane-3β,11β,20β,21-tetrol: 91 ± 25μg). The excretion of corticosteroids was cyclic in both female and male rats with the maximum excretion between 16.00 and 22.00 h and the minimum excretion between 04.00 and 10.00 h. The daily rhythm of corticosteroid excretion was disturbed for at least two days by operative manipulations in connection with bile duct cannulation, by intraperitoneal administration of saline and by intramuscular administration of dimethylsulphoxide.
AB - The excretion of corticosteroids in bile has been studied in female and male rats. The total daily excretion of corticosteroids in female rats was 738 ± 169 ms (3α,11β,15α,21-tetrahydroxy-5α-pregnan-20-one monosulphate: 300 ± 16 μg; 3α,11β,15α,21-tetrahydroxy-5α-pregnan-20-one disulphate: 158 ± 51 μg; 3α,11β,21-trihydroxy-5α-pregnan-20-one disulphate: 146 ± 49 μg; and 3β,11β,21-trihydroxy-5α-pregnan-20-one disulphate: 134 ± 38μg) and in male rats the corresponding figure was 773 ± 97 μg (3β,11β,21-trihydroxy-5α-pregnan-20-one disulphate: 682 ± 72 μg; and 5α-pregnane-3β,11β,20β,21-tetrol: 91 ± 25μg). The excretion of corticosteroids was cyclic in both female and male rats with the maximum excretion between 16.00 and 22.00 h and the minimum excretion between 04.00 and 10.00 h. The daily rhythm of corticosteroid excretion was disturbed for at least two days by operative manipulations in connection with bile duct cannulation, by intraperitoneal administration of saline and by intramuscular administration of dimethylsulphoxide.
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U2 - 10.1016/0022-4731(73)90009-5
DO - 10.1016/0022-4731(73)90009-5
M3 - Article
C2 - 4747983
AN - SCOPUS:0015855835
VL - 4
SP - 393
EP - 400
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
SN - 0022-4731
IS - 4
ER -