Distribution of the mammalian stat gene family in mouse chromosomes

Neal G. Copeland; Debra J. Gilbert; Chris Schindler; Zhong Zhong; Zilong Wen; James E. Darnell; Alice L.F. Mui; Atsushi Miyajima; Frederick W. Quelle; James N. Ihle; Nancy A. Jenkins

doi:10.1006/geno.1995.1235

Distribution of the mammalian stat gene family in mouse chromosomes

Neal G. Copeland, Debra J. Gilbert, Chris Schindler, Zhong Zhong, Zilong Wen, James E. Darnell, Alice L.F. Mui, Atsushi Miyajima, Frederick W. Quelle, James N. Ihle, Nancy A. Jenkins

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175 Scopus citations

Abstract

Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes.

Original language	English (US)
Pages (from-to)	225-228
Number of pages	4
Journal	Genomics
Volume	29
Issue number	1
DOIs	https://doi.org/10.1006/geno.1995.1235
State	Published - Sep 1 1995

ASJC Scopus subject areas

Genetics

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abstract = "Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes.",

author = "Copeland, {Neal G.} and Gilbert, {Debra J.} and Chris Schindler and Zhong Zhong and Zilong Wen and Darnell, {James E.} and Mui, {Alice L.F.} and Atsushi Miyajima and Quelle, {Frederick W.} and Ihle, {James N.} and Jenkins, {Nancy A.}",

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AU - Gilbert, Debra J.

AU - Schindler, Chris

AU - Zhong, Zhong

AU - Wen, Zilong

AU - Darnell, James E.

AU - Mui, Alice L.F.

AU - Miyajima, Atsushi

AU - Quelle, Frederick W.

AU - Ihle, James N.

AU - Jenkins, Nancy A.

PY - 1995/9/1

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N2 - Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes.

AB - Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes.

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Distribution of the mammalian stat gene family in mouse chromosomes

Abstract

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