Distribution of the mammalian stat gene family in mouse chromosomes

Neal G. Copeland, Debra J. Gilbert, Chris Schindler, Zhong Zhong, Zilong Wen, James E. Darnell, Alice L.F. Mui, Atsushi Miyajima, Frederick W. Quelle, James N. Ihle, Nancy A. Jenkins

Research output: Contribution to journalArticlepeer-review

157 Scopus citations

Abstract

Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalGenomics
Volume29
Issue number1
DOIs
StatePublished - Sep 1 1995

ASJC Scopus subject areas

  • Genetics

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