Distribution of streptococcus pneumoniae resistant to penicillin in the USA and in-vitro susceptibility to selected oral antibiotics

Edward O. Mason, Linda Lamberth, Rebekah Lichenstein, Sheldon L. Kaplan

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Surveillance by 33 laboratories in 19 states during a 4 1/2 month period between December 1993 and April 1994 found that 263 of 1627 (16.2%) isolates of Streptococcus pneumoniae were resistant to penicillin. One hundred and seventy (10.4%) isolates were determined to be intermediately resistant to penicillin (MICs 0.1-1.0 mg/L and 93 (5.7%) were found to be highly resistant to penicillin (MICs > 2.0 mg/L). MIC(90s) for intermediately penicillin resistant strains were: amoxycillin/clavulanate 2.0 mg/L, cefaclor 64 mg/L, cefixime 32 mg/L, cefprozil 8 mg/L and loracarbef 128 mg/L. MIC(90s) for highly penicillin resistant strains were: amoxycillin/clavulanate 4.0 mg/L, cefaclor ≥ 128 mg/L cefixime 64 mg/L, cefprozil 32 mg/L and loracarbef ≥ 128 mg/L.

Original languageEnglish (US)
Pages (from-to)1043-1048
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume36
Issue number6
DOIs
StatePublished - Dec 1995

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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