Distribution of fibronectin-binding proteins among group a streptococci of different m types

Shira Natanson, Shlomo Sela, Allon E. Moses, James M. Musser, Michael G. Caparon, Emanuel Hanski

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Binding of fibronectin by group A streptococci (GAS) promotes adherence to epithelial cells. The fibronectin-binding activity and the presence of prtF, a gene encoding a fibronectin-binding protein, were studied among 109 strains. Fifty-six strains of 42 different M types possessed prtF-related genes, and 89% of these strains bound fibronectin at high levels. The prtF- related genes varied in the number of repeats that constitute one of its two fibronectin-binding domains. Fifty-three strains of 21 different M types lacked prtF. Thirty-nine of these (74%), representing 13 different M types, bound fibronectin at very low levels. However, 9 (17%), of 5 different M types, bound fibronectin at high levels. The presence of prtF and the capacity to bind fibronectin correlated strongly with the M type of various strains of GAS. This correlation may suggest the existence of a relationship between fibronectin binding and the pathogenic potential of GAS.

Original languageEnglish (US)
Pages (from-to)871-878
Number of pages8
JournalJournal of Infectious Diseases
Volume171
Issue number4
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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