Distinct serum cytokines in AIDS-related skin diseases

Joan N. Breuer-McHam, Gailen D. Marshall, Dorothy E. Lewis, Madeleine Duvic

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

To determine whether common skin diseases associated with human immunodeficiency virus (HIV) were distinguishable based on the pattern of serum cytokine expression, we studied patients with psoriasis, pruritus, and Kaposi's sarcoma (KS) for levels of tumor necrosis factor (TNF)-α, interferon-gamma (IFN-γ), interleukin (IL)-10, and IL-4. Thirty-two HIV-positive (HIV+) patients including 8 with KS, 11 with psoriasis, and 13 with pruritus along with 16 HIV-negative subjects with psoriasis were studied. IFN-γ levels were highest in sera of HIV+ patients with psoriasis (p = 0.040). By contrast, TNF-α and IL-10 levels were highest in sera of HIV+ patients with pruritus (p = 0.012). Detectable levels of all cytokines in these patients were remarkably higher than for healthy adults. These results suggest that common skin diseases associated with HIV infection and AIDS can be distinguished by the production of unique cytokines.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalViral Immunology
Volume11
Issue number4
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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