Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.
|Original language||English (US)|
|Number of pages||17|
|Journal||Journal of Biological Chemistry|
|State||Published - Dec 27 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology