Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690

Venkatesh L. Hegde, Sunil Tomar, Austin Jackson, Roshni Rao, Xiaoming Yang, Udai P. Singh, Narendra P. Singh, Prakash S. Nagarkatti, Mitzi Nagarkatti

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)36810-36826
Number of pages17
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
StatePublished - Dec 27 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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