Abstract
Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.
Original language | English (US) |
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Pages (from-to) | 36810-36826 |
Number of pages | 17 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 52 |
DOIs | |
State | Published - Dec 27 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology