Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690

Venkatesh L. Hegde, Sunil Tomar, Austin Jackson, Roshni Rao, Xiaoming Yang, Udai P. Singh, Narendra P. Singh, Prakash S. Nagarkatti, Mitzi Nagarkatti

    Research output: Contribution to journalArticlepeer-review

    83 Scopus citations

    Abstract

    Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.

    Original languageEnglish (US)
    Pages (from-to)36810-36826
    Number of pages17
    JournalJournal of Biological Chemistry
    Volume288
    Issue number52
    DOIs
    StatePublished - Dec 27 2013

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Fingerprint

    Dive into the research topics of 'Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690'. Together they form a unique fingerprint.

    Cite this