Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690

Venkatesh L. Hegde; Sunil Tomar; Austin Jackson; Roshni Rao; Xiaoming Yang; Udai P. Singh; Narendra P. Singh; Prakash S. Nagarkatti; Mitzi Nagarkatti

doi:10.1074/jbc.M113.503037

Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ⁹- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690

Venkatesh L. Hegde, Sunil Tomar, Austin Jackson, Roshni Rao, Xiaoming Yang, Udai P. Singh, Narendra P. Singh, Prakash S. Nagarkatti, Mitzi Nagarkatti

Research Institute

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.

Original language	English (US)
Pages (from-to)	36810-36826
Number of pages	17
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.503037
State	Published - Dec 27 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.503037

Fingerprint

Dive into the research topics of 'Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ⁹- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690'. Together they form a unique fingerprint.

Cite this

Hegde, V. L., Tomar, S., Jackson, A., Rao, R., Yang, X., Singh, U. P., Singh, N. P., Nagarkatti, P. S., & Nagarkatti, M. (2013). Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ⁹- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690. Journal of Biological Chemistry, 288(52), 36810-36826. https://doi.org/10.1074/jbc.M113.503037

Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ⁹- tetrahydrocannabinol in Vivo : Regulation of CCAAT/enhancer-binding proteinα by microRNA-690. / Hegde, Venkatesh L.; Tomar, Sunil; Jackson, Austin et al.

In: Journal of Biological Chemistry, Vol. 288, No. 52, 27.12.2013, p. 36810-36826.

Research output: Contribution to journal › Article › peer-review

Hegde, VL, Tomar, S, Jackson, A, Rao, R, Yang, X, Singh, UP, Singh, NP, Nagarkatti, PS & Nagarkatti, M 2013, 'Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ⁹- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690', Journal of Biological Chemistry, vol. 288, no. 52, pp. 36810-36826. https://doi.org/10.1074/jbc.M113.503037

Hegde VL, Tomar S, Jackson A, Rao R, Yang X, Singh UP et al. Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ⁹- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690. Journal of Biological Chemistry. 2013 Dec 27;288(52):36810-36826. https://doi.org/10.1074/jbc.M113.503037

@article{978184f3cf6e4edc966b2955608dcd91,

title = "Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9- tetrahydrocannabinol in Vivo: Regulation of CCAAT/enhancer-binding proteinα by microRNA-690",

abstract = "Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.",

author = "Hegde, {Venkatesh L.} and Sunil Tomar and Austin Jackson and Roshni Rao and Xiaoming Yang and Singh, {Udai P.} and Singh, {Narendra P.} and Nagarkatti, {Prakash S.} and Mitzi Nagarkatti",

year = "2013",

month = dec,

day = "27",

doi = "10.1074/jbc.M113.503037",

language = "English (US)",

volume = "288",

pages = "36810--36826",

journal = "The Journal of biological chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "52",

}

TY - JOUR

T1 - Distinct MicroRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9- tetrahydrocannabinol in Vivo

T2 - Regulation of CCAAT/enhancer-binding proteinα by microRNA-690

AU - Hegde, Venkatesh L.

AU - Tomar, Sunil

AU - Jackson, Austin

AU - Rao, Roshni

AU - Yang, Xiaoming

AU - Singh, Udai P.

AU - Singh, Narendra P.

AU - Nagarkatti, Prakash S.

AU - Nagarkatti, Mitzi

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.

AB - Background: Cannabinoids induce potent myeloid-derived suppressor cells (MDSCs) in vivo. Results: Functional MDSCs induced by THC show distinct miRNA expression patterns. Conclusion: Specific miRNA may play important roles in MDSC development and function by regulating target genes involved in myeloid cell differentiation. Significance: Select miRNA could be important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.

UR - http://www.scopus.com/inward/record.url?scp=84891408224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891408224&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.503037

DO - 10.1074/jbc.M113.503037

M3 - Article

AN - SCOPUS:84891408224

VL - 288

SP - 36810

EP - 36826

JO - The Journal of biological chemistry

JF - The Journal of biological chemistry

SN - 0021-9258

IS - 52

ER -