Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia

Adriana Correa; Rosa Del Campo; Marcela Perenguez; Victor M. Blanco; Mercedes Rodríguez-Baños; Federico Perez; Juan J. Maya; Laura Rojas; Rafael Cantón; Cesar A. Arias; Maria V. Villegas

doi:10.1128/AAC.03926-14

Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia

Adriana Correa, Rosa Del Campo, Marcela Perenguez, Victor M. Blanco, Mercedes Rodríguez-Baños, Federico Perez, Juan J. Maya, Laura Rojas, Rafael Cantón, Cesar A. Arias, Maria V. Villegas

Houston Methodist

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor bla_VIM-2on a class 1 integron and bla_KPC-2 on a Tn4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.

Original language	English (US)
Pages (from-to)	2421-2425
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	4
DOIs	https://doi.org/10.1128/AAC.03926-14
State	Published - Apr 1 2015

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2on a class 1 integron and blaKPC-2 on a Tn4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.",

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AU - Correa, Adriana

AU - Del Campo, Rosa

AU - Perenguez, Marcela

AU - Blanco, Victor M.

AU - Rodríguez-Baños, Mercedes

AU - Perez, Federico

AU - Maya, Juan J.

AU - Rojas, Laura

AU - Cantón, Rafael

AU - Arias, Cesar A.

AU - Villegas, Maria V.

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AB - The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2on a class 1 integron and blaKPC-2 on a Tn4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.

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Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia

Abstract

ASJC Scopus subject areas

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