Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury

N Oliver, T Luong, A Tchakarov, M Abdelrahim, Victor E. Mulanovich, D. P. Kontoyiannis, R. Jones, Partow Kebriaei, Joshua A. Samuels, John W. Glass, A. Abudayyeh

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. However, immunosuppression, polypharmacy and risk of infectious complications associated with HSCT can increase morbidity and mortality for recipients. Incidence of acute kidney injury (AKI) after HSCT can be as high as 70%, and concomitant infection can be a therapeutic challenge for oncologists, nephrologists and infectious disease specialists. We illustrate this challenge in the case of a 31-year-old man with acute lymphoblastic leukemia who underwent a double cord HSCT complicated by GvHD, systemic cryptococcal and BK virus infections and AKI. Kidney biopsy showed round to cup-shaped organisms with occasional budding, consistent with Cryptococcus and thrombotic microangiopathy. We discuss our findings and a literature review of disseminated cryptococcal infection with renal involvement after HSCT.

Original languageEnglish (US)
Pages (from-to)1301-1304
Number of pages4
JournalBone Marrow Transplantation
Volume51
Issue number10
DOIs
StatePublished - Oct 2016

Keywords

  • Journal Article

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