Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury

N Oliver; T Luong; A Tchakarov; M Abdelrahim; Victor E. Mulanovich; D. P. Kontoyiannis; R. Jones; Partow Kebriaei; Joshua A. Samuels; John W. Glass; A. Abudayyeh

doi:10.1038/bmt.2016.120

Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury

N Oliver, T Luong, A Tchakarov, M Abdelrahim, Victor E. Mulanovich, D. P. Kontoyiannis, R. Jones, Partow Kebriaei, Joshua A. Samuels, John W. Glass, A. Abudayyeh

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Abstract

Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. However, immunosuppression, polypharmacy and risk of infectious complications associated with HSCT can increase morbidity and mortality for recipients. Incidence of acute kidney injury (AKI) after HSCT can be as high as 70%, and concomitant infection can be a therapeutic challenge for oncologists, nephrologists and infectious disease specialists. We illustrate this challenge in the case of a 31-year-old man with acute lymphoblastic leukemia who underwent a double cord HSCT complicated by GvHD, systemic cryptococcal and BK virus infections and AKI. Kidney biopsy showed round to cup-shaped organisms with occasional budding, consistent with Cryptococcus and thrombotic microangiopathy. We discuss our findings and a literature review of disseminated cryptococcal infection with renal involvement after HSCT.

Original language	English (US)
Pages (from-to)	1301-1304
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	51
Issue number	10
DOIs	https://doi.org/10.1038/bmt.2016.120
State	Published - Oct 2016

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Oliver, N., Luong, T., Tchakarov, A., Abdelrahim, M., Mulanovich, V. E., Kontoyiannis, D. P., Jones, R., Kebriaei, P., Samuels, J. A., Glass, J. W., & Abudayyeh, A. (2016). Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury. Bone Marrow Transplantation, 51(10), 1301-1304. https://doi.org/10.1038/bmt.2016.120

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title = "Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury",

abstract = "Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. However, immunosuppression, polypharmacy and risk of infectious complications associated with HSCT can increase morbidity and mortality for recipients. Incidence of acute kidney injury (AKI) after HSCT can be as high as 70%, and concomitant infection can be a therapeutic challenge for oncologists, nephrologists and infectious disease specialists. We illustrate this challenge in the case of a 31-year-old man with acute lymphoblastic leukemia who underwent a double cord HSCT complicated by GvHD, systemic cryptococcal and BK virus infections and AKI. Kidney biopsy showed round to cup-shaped organisms with occasional budding, consistent with Cryptococcus and thrombotic microangiopathy. We discuss our findings and a literature review of disseminated cryptococcal infection with renal involvement after HSCT.",

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T2 - a rare cause of acute kidney injury

AU - Oliver, N

AU - Luong, T

AU - Tchakarov, A

AU - Abdelrahim, M

AU - Mulanovich, Victor E.

AU - Kontoyiannis, D. P.

AU - Jones, R.

AU - Kebriaei, Partow

AU - Samuels, Joshua A.

AU - Glass, John W.

AU - Abudayyeh, A.

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N2 - Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. However, immunosuppression, polypharmacy and risk of infectious complications associated with HSCT can increase morbidity and mortality for recipients. Incidence of acute kidney injury (AKI) after HSCT can be as high as 70%, and concomitant infection can be a therapeutic challenge for oncologists, nephrologists and infectious disease specialists. We illustrate this challenge in the case of a 31-year-old man with acute lymphoblastic leukemia who underwent a double cord HSCT complicated by GvHD, systemic cryptococcal and BK virus infections and AKI. Kidney biopsy showed round to cup-shaped organisms with occasional budding, consistent with Cryptococcus and thrombotic microangiopathy. We discuss our findings and a literature review of disseminated cryptococcal infection with renal involvement after HSCT.

AB - Hematopoietic stem cell transplantation (HSCT) can be lifesaving for some of the deadliest hematologic diseases. However, immunosuppression, polypharmacy and risk of infectious complications associated with HSCT can increase morbidity and mortality for recipients. Incidence of acute kidney injury (AKI) after HSCT can be as high as 70%, and concomitant infection can be a therapeutic challenge for oncologists, nephrologists and infectious disease specialists. We illustrate this challenge in the case of a 31-year-old man with acute lymphoblastic leukemia who underwent a double cord HSCT complicated by GvHD, systemic cryptococcal and BK virus infections and AKI. Kidney biopsy showed round to cup-shaped organisms with occasional budding, consistent with Cryptococcus and thrombotic microangiopathy. We discuss our findings and a literature review of disseminated cryptococcal infection with renal involvement after HSCT.

KW - Journal Article

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DO - 10.1038/bmt.2016.120

M3 - Article

C2 - 27159179

SN - 0268-3369

VL - 51

SP - 1301

EP - 1304

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 10

ER -

Disseminated cryptococcal infection in allogeneic stem cell transplant patients: a rare cause of acute kidney injury

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