Disproportionate loss of CA4 parvalbumin-immunoreactive interneurons in patients with Ammon's horn sclerosis

Zhen Qing Zhu, Dawna L. Armstrong, Winifred J. Hamilton, Robert G. Grossman

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

We studied differences in the number and morphology of parvalbumin- immunoreactive (PV-IR) interneurons in 43 hippocampal specimens from patients with classical Ammo's horn sclerosis (AHS) who underwent anterior temporal lobectomy, as compared with 14 autopsy and non-AHS surgical control specimens. PV-IR neuronal loss in the AHS specimens varied significantly from that expected based on overall AHS-associated pyramidal and granule neuron loss. Most striking was the loss of PV-IR interneurons in CA4 of the AHS specimens, which was 12 times greater than AHS-associated pyramidal neuron loss, and significantly exceeded the PV-IR interneuron loss observed in the other sectors of the hippocampus. In addition, the PV-IR interneurons in the AHS specimens had markedly smaller and less defined cell bodies and shortened and simplified dendritic arbors compared with the PV-IR interneurons in the control specimens. Other differences noted in the AHS specimens included prominent dendritic varicosities; the loss or interruption of a band formed by PV-IR terminals in the dentate gyms; and the virtual absence of a small, intensely staining PV-IR interneuron with a short, exuberant dendritic arbor that was readily identified in the autopsy specimens. We discuss these findings in relationship to the development of classical AHS and complex partial seizures (CPS).

Original languageEnglish (US)
Pages (from-to)988-998
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume56
Issue number9
DOIs
StatePublished - Jan 1 1997

Keywords

  • Calcium-binding proteins
  • Epilepsy
  • Hippocampus
  • Parvalbumin
  • Temporal lobe

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

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