Abstract
We studied differences in the number and morphology of parvalbumin- immunoreactive (PV-IR) interneurons in 43 hippocampal specimens from patients with classical Ammo's horn sclerosis (AHS) who underwent anterior temporal lobectomy, as compared with 14 autopsy and non-AHS surgical control specimens. PV-IR neuronal loss in the AHS specimens varied significantly from that expected based on overall AHS-associated pyramidal and granule neuron loss. Most striking was the loss of PV-IR interneurons in CA4 of the AHS specimens, which was 12 times greater than AHS-associated pyramidal neuron loss, and significantly exceeded the PV-IR interneuron loss observed in the other sectors of the hippocampus. In addition, the PV-IR interneurons in the AHS specimens had markedly smaller and less defined cell bodies and shortened and simplified dendritic arbors compared with the PV-IR interneurons in the control specimens. Other differences noted in the AHS specimens included prominent dendritic varicosities; the loss or interruption of a band formed by PV-IR terminals in the dentate gyms; and the virtual absence of a small, intensely staining PV-IR interneuron with a short, exuberant dendritic arbor that was readily identified in the autopsy specimens. We discuss these findings in relationship to the development of classical AHS and complex partial seizures (CPS).
Original language | English (US) |
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Pages (from-to) | 988-998 |
Number of pages | 11 |
Journal | Journal of Neuropathology and Experimental Neurology |
Volume | 56 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1997 |
Keywords
- Calcium-binding proteins
- Epilepsy
- Hippocampus
- Parvalbumin
- Temporal lobe
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- General Neuroscience