Disproportional body growth in female estrogen receptor-α-inactivated mice

O. Vidal; M. Lindberg; L. Sävendahl; D. B. Lubahn; E. M. Ritzen; J. Å Gustafsson; C. Ohlsson

doi:10.1006/bbrc.1999.1711

Disproportional body growth in female estrogen receptor-α-inactivated mice

O. Vidal, M. Lindberg, L. Sävendahl, D. B. Lubahn, E. M. Ritzen, J. Å Gustafsson, C. Ohlsson

Research Institute

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Abstract

Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERα and ERβ, have been cloned. The aim of the present study was to investigate the function of ERα in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERα (ERα-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERα-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERα-/- mice.

Original language	English (US)
Pages (from-to)	569-571
Number of pages	3
Journal	Biochemical and Biophysical Research Communications
Volume	265
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1999.1711
State	Published - Nov 19 1999

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Disproportional body growth in female estrogen receptor-α-inactivated mice",

abstract = "Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERα and ERβ, have been cloned. The aim of the present study was to investigate the function of ERα in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERα (ERα-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERα-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERα-/- mice.",

author = "O. Vidal and M. Lindberg and L. S{\"a}vendahl and Lubahn, {D. B.} and Ritzen, {E. M.} and Gustafsson, {J. {\AA}} and C. Ohlsson",

note = "Funding Information: This study was supported by the Swedish Medical Research Council, the Bergvall Foundation, the Lundberg Foundation, and the Swedish Association Against Rheumatic Disease, the Novo Nordisk Foundation.",

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doi = "10.1006/bbrc.1999.1711",

language = "English (US)",

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AU - Vidal, O.

AU - Lindberg, M.

AU - Sävendahl, L.

AU - Lubahn, D. B.

AU - Ritzen, E. M.

AU - Gustafsson, J. Å

AU - Ohlsson, C.

N1 - Funding Information: This study was supported by the Swedish Medical Research Council, the Bergvall Foundation, the Lundberg Foundation, and the Swedish Association Against Rheumatic Disease, the Novo Nordisk Foundation.

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Y1 - 1999/11/19

N2 - Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERα and ERβ, have been cloned. The aim of the present study was to investigate the function of ERα in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERα (ERα-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERα-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERα-/- mice.

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Disproportional body growth in female estrogen receptor-α-inactivated mice

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