Discovery of 5-substituted pyrrolo[2,3- d ]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: Implications of inhibiting 5-aminoimidazole-4- carboxamide ribonucleotide formyltransferase to AMPK activation and antitumor activity

Shermaine Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan, Manasa Punaha Ravindra, Eric Hales, Steven Orr, Christina Cherian, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee

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