Discovering molecular targets in cancer with multiscale modeling

Zhihui Wang, Veronika Bordas, Thomas S. Deisboeck

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

(Table Presented) Multiscale modeling is being recognized increasingly as a promising research area in computational cancer systems biology. In the present review, exemplified by two pioneering studies, we attempt to explain why and how such a multiscale approach paired with an innovative cross-scale analytical technique can be useful in identifying high-value molecular therapeutic targets. This novel, integrated approach has the potential to offer a more effective in silico framework for target discovery and represents an important technical step toward systems medicine.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalDrug Development Research
Volume72
Issue number1
DOIs
StatePublished - Feb 1 2011

Keywords

  • Computational modeling
  • Epidermal growth factor receptor
  • Multiscale
  • Non-small cell lung cancer
  • Signaling pathway

ASJC Scopus subject areas

  • Drug Discovery

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