TY - JOUR
T1 - Direct Assessment of the Toxicity of Molybdenum Disulfide Atomically Thin Film and Microparticles via Cytotoxicity and Patch Testing
AU - Chen, Weibing
AU - Qi, Wenjin
AU - Lu, Wei
AU - Chaudhury, Nikhil Roy
AU - Yuan, Jiangtan
AU - Qin, Lidong
AU - Lou, Jun
N1 - Funding Information:
The authors gratefully acknowledge the support from the AFOSR grant FA9550-14-1-0268 and the Welch Foundation Grant C-1716, National Natural Science Foundation of China (NSFC, Grant No. 81660248) and the Project for Young Academic and Technology leaders in Yunnan Province (Grant No. 2012HB029).
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/3/22
Y1 - 2018/3/22
N2 - The low toxicity of molybdenum disulfide (MoS2) atomically thin film and microparticles is confirmed via cytotoxicity and patch testing in this report. The toxicity of MoS2 thin film and microparticles is extensively studied but is still inconclusive due to potential organic contamination in the preparations of samples. Such contamination is avoided here through preparing MoS2 atomically thin film via direct sulfurization of molybdenum thin film on quartz plate, which permits a direct assessment of its toxicity without any contamination. Six different types of cells, including normal, cancer, and immortal cells, are cultured in the media containing MoS2 thin film on quartz plates or dispersed MoS2 microparticles and their viability is evaluated with respect to the concentrations of samples. Detached thin films from the quartz plates are also investigated to estimate the toxicity of dispersed MoS2 in biological media. Allergy testing on skin of guinea pigs is also conducted to understand their effect on animal skins. By avoiding possible organic contamination, the low toxicity of MoS2 atomically thin film and microparticles to cells and animal skins paves the way for its applications in flexible biosensing/bioimaging devices and biocompatible coatings.
AB - The low toxicity of molybdenum disulfide (MoS2) atomically thin film and microparticles is confirmed via cytotoxicity and patch testing in this report. The toxicity of MoS2 thin film and microparticles is extensively studied but is still inconclusive due to potential organic contamination in the preparations of samples. Such contamination is avoided here through preparing MoS2 atomically thin film via direct sulfurization of molybdenum thin film on quartz plate, which permits a direct assessment of its toxicity without any contamination. Six different types of cells, including normal, cancer, and immortal cells, are cultured in the media containing MoS2 thin film on quartz plates or dispersed MoS2 microparticles and their viability is evaluated with respect to the concentrations of samples. Detached thin films from the quartz plates are also investigated to estimate the toxicity of dispersed MoS2 in biological media. Allergy testing on skin of guinea pigs is also conducted to understand their effect on animal skins. By avoiding possible organic contamination, the low toxicity of MoS2 atomically thin film and microparticles to cells and animal skins paves the way for its applications in flexible biosensing/bioimaging devices and biocompatible coatings.
KW - cytotoxicity
KW - microparticles
KW - molybdenum disulfide
KW - thin films
KW - toxicity evaluation
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U2 - 10.1002/smll.201702600
DO - 10.1002/smll.201702600
M3 - Article
C2 - 29356309
AN - SCOPUS:85044397765
VL - 14
JO - Small
JF - Small
SN - 1613-6810
IS - 12
M1 - 1702600
ER -