Direct and consensual murine pupillary reflex metrics: Establishing normative values

Research output: Contribution to journalArticle

Rehana Z. Hussain, Steven C. Hopkins, Elliot M. Frohman, Todd N. Eagar, Petra C. Cravens, Benjamin M. Greenberg, Steven Vernino, Olaf Stüve

Pupillometry is a non-invasive technique, based on well-established neurophysiologic principles, that can be utilized to objectively characterize pathophysiologic demyelinating and neurodegenerative changes involving the pupillary reflex pathway. In animal models of human disorders, pupillometry derived reflex metrics could potentially be used to longitudinally monitor disease activity and responses to pharmacotherapies. These investigations would have important implications for translational initiatives focused on the identification and application of novel neuroprotective and restorative treatments for human diseases such as multiple sclerosis. Here, we have established normal reference values for various pupillary reflex metrics across different mouse strains. Ultimately, we anticipate that this new data will help to catalyze unique lines of inquiry using pupillometry methods.

Original languageEnglish (US)
Pages (from-to)164-167
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Volume151
Issue number2
DOIs
StatePublished - Dec 3 2009

PMID: 19683968

PMCID: PMC3902806

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Standard

Direct and consensual murine pupillary reflex metrics : Establishing normative values. / Hussain, Rehana Z.; Hopkins, Steven C.; Frohman, Elliot M.; Eagar, Todd N.; Cravens, Petra C.; Greenberg, Benjamin M.; Vernino, Steven; Stüve, Olaf.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 151, No. 2, 03.12.2009, p. 164-167.

Research output: Contribution to journalArticle

Harvard

Hussain, RZ, Hopkins, SC, Frohman, EM, Eagar, TN, Cravens, PC, Greenberg, BM, Vernino, S & Stüve, O 2009, 'Direct and consensual murine pupillary reflex metrics: Establishing normative values' Autonomic Neuroscience: Basic and Clinical, vol. 151, no. 2, pp. 164-167. https://doi.org/10.1016/j.autneu.2009.07.021

APA

Hussain, R. Z., Hopkins, S. C., Frohman, E. M., Eagar, T. N., Cravens, P. C., Greenberg, B. M., ... Stüve, O. (2009). Direct and consensual murine pupillary reflex metrics: Establishing normative values. Autonomic Neuroscience: Basic and Clinical, 151(2), 164-167. https://doi.org/10.1016/j.autneu.2009.07.021

Vancouver

Hussain RZ, Hopkins SC, Frohman EM, Eagar TN, Cravens PC, Greenberg BM et al. Direct and consensual murine pupillary reflex metrics: Establishing normative values. Autonomic Neuroscience: Basic and Clinical. 2009 Dec 3;151(2):164-167. https://doi.org/10.1016/j.autneu.2009.07.021

Author

Hussain, Rehana Z. ; Hopkins, Steven C. ; Frohman, Elliot M. ; Eagar, Todd N. ; Cravens, Petra C. ; Greenberg, Benjamin M. ; Vernino, Steven ; Stüve, Olaf. / Direct and consensual murine pupillary reflex metrics : Establishing normative values. In: Autonomic Neuroscience: Basic and Clinical. 2009 ; Vol. 151, No. 2. pp. 164-167.

BibTeX

@article{a3938aa093ca4f27b0b55f02b640e18b,
title = "Direct and consensual murine pupillary reflex metrics: Establishing normative values",
abstract = "Pupillometry is a non-invasive technique, based on well-established neurophysiologic principles, that can be utilized to objectively characterize pathophysiologic demyelinating and neurodegenerative changes involving the pupillary reflex pathway. In animal models of human disorders, pupillometry derived reflex metrics could potentially be used to longitudinally monitor disease activity and responses to pharmacotherapies. These investigations would have important implications for translational initiatives focused on the identification and application of novel neuroprotective and restorative treatments for human diseases such as multiple sclerosis. Here, we have established normal reference values for various pupillary reflex metrics across different mouse strains. Ultimately, we anticipate that this new data will help to catalyze unique lines of inquiry using pupillometry methods.",
keywords = "Experimental autoimmune encephalomyelitis, Mouse models, Multiple sclerosis, Pupillometry",
author = "Hussain, {Rehana Z.} and Hopkins, {Steven C.} and Frohman, {Elliot M.} and Eagar, {Todd N.} and Cravens, {Petra C.} and Greenberg, {Benjamin M.} and Steven Vernino and Olaf St{\"u}ve",
year = "2009",
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issn = "1566-0702",
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RIS

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T1 - Direct and consensual murine pupillary reflex metrics

T2 - Autonomic Neuroscience: Basic and Clinical

AU - Hussain, Rehana Z.

AU - Hopkins, Steven C.

AU - Frohman, Elliot M.

AU - Eagar, Todd N.

AU - Cravens, Petra C.

AU - Greenberg, Benjamin M.

AU - Vernino, Steven

AU - Stüve, Olaf

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Y1 - 2009/12/3

N2 - Pupillometry is a non-invasive technique, based on well-established neurophysiologic principles, that can be utilized to objectively characterize pathophysiologic demyelinating and neurodegenerative changes involving the pupillary reflex pathway. In animal models of human disorders, pupillometry derived reflex metrics could potentially be used to longitudinally monitor disease activity and responses to pharmacotherapies. These investigations would have important implications for translational initiatives focused on the identification and application of novel neuroprotective and restorative treatments for human diseases such as multiple sclerosis. Here, we have established normal reference values for various pupillary reflex metrics across different mouse strains. Ultimately, we anticipate that this new data will help to catalyze unique lines of inquiry using pupillometry methods.

AB - Pupillometry is a non-invasive technique, based on well-established neurophysiologic principles, that can be utilized to objectively characterize pathophysiologic demyelinating and neurodegenerative changes involving the pupillary reflex pathway. In animal models of human disorders, pupillometry derived reflex metrics could potentially be used to longitudinally monitor disease activity and responses to pharmacotherapies. These investigations would have important implications for translational initiatives focused on the identification and application of novel neuroprotective and restorative treatments for human diseases such as multiple sclerosis. Here, we have established normal reference values for various pupillary reflex metrics across different mouse strains. Ultimately, we anticipate that this new data will help to catalyze unique lines of inquiry using pupillometry methods.

KW - Experimental autoimmune encephalomyelitis

KW - Mouse models

KW - Multiple sclerosis

KW - Pupillometry

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U2 - 10.1016/j.autneu.2009.07.021

DO - 10.1016/j.autneu.2009.07.021

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JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

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ID: 16777946