Diminished value discrimination in obsessive-compulsive disorder: A prospect theory model of decision-making under risk

Sophie A. George, Jony Sheynin, Richard Gonzalez, Israel Liberzon, James L. Abelson

Research output: Contribution to journalArticle

Abstract

Introduction: It has been hypothesized that people diagnosed with anxiety and obsessive-compulsive disorder (OCD) exhibit behavioral aberrations when faced with the potential for negative outcomes, but the specific cognitive aspects of decision-making that may be altered have not been systematically studied in clinical populations. Here, we studied decision-making in a clinical cohort using a task that allows for examination of the decision weights and values associated with different choice outcomes. Methods: Patients diagnosed with OCD (n = 10), generalized anxiety disorder (n = 15), social anxiety disorder (n = 14), and healthy controls (n = 20) were given a decision-making task and choices were modeled using a cumulative prospect theory framework. Results: We found OCD patients to have lower value discrimination than controls, as well as less optimal performance on the task, an effect that was mostly driven by trials with only positive outcomes. Discussion: Our results shed light on the cognitive processes that drive altered decision-making under risk in OCD. Specifically, they demonstrate that OCD patients have diminished sensitivity to positive outcomes, which might be associated with risk aversion and altered learning of gain. These findings also extend prior reports, suggesting that altered cognitive processing during decision-making is linked to altered perception of value, but not probability, in these patients.

Original languageEnglish (US)
Article number469
JournalFrontiers in Psychiatry
Volume10
Issue numberJULY
DOIs
StatePublished - 2019

Keywords

  • Decision-making
  • Obsessive-compulsive disorder
  • Positive outcome
  • Prospect theory
  • Risk aversion

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Diminished value discrimination in obsessive-compulsive disorder: A prospect theory model of decision-making under risk'. Together they form a unique fingerprint.

Cite this