Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

Nancy A. Jenkins; Neal G. Copeland; Benjamin A. Taylor; Barbara K. Lee

doi:10.1038/293370a0

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

Nancy A. Jenkins, Neal G. Copeland, Benjamin A. Taylor, Barbara K. Lee

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Abstract

The single endogenous DBA/2J ecotropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d(+2J)) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute resulted from integration of an ecotropic provirus into the mouse genome.

Original language	English (US)
Pages (from-to)	370-374
Number of pages	5
Journal	Nature
Volume	293
Issue number	5831
DOIs	https://doi.org/10.1038/293370a0
State	Published - Dec 1 1981

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abstract = "The single endogenous DBA/2J ecotropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d(+2J)) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute resulted from integration of an ecotropic provirus into the mouse genome.",

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AU - Taylor, Benjamin A.

AU - Lee, Barbara K.

PY - 1981/12/1

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AB - The single endogenous DBA/2J ecotropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d(+2J)) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute resulted from integration of an ecotropic provirus into the mouse genome.

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Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

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