Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

Nancy A. Jenkins, Neal G. Copeland, Benjamin A. Taylor, Barbara K. Lee

Research output: Contribution to journalArticle

222 Scopus citations

Abstract

The single endogenous DBA/2J ecotropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d(+2J)) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute resulted from integration of an ecotropic provirus into the mouse genome.

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalNature
Volume293
Issue number5831
DOIs
StatePublished - Dec 1 1981

ASJC Scopus subject areas

  • General

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