Diffuse Bone Marrow Involvement of Hodgkin Lymphoma Mimics Hematopoietic Cytokine-Mediated FDG uptake on FDG PET Imaging

Stephen Chiang, Alan Rebenstock, Liang Guan, Abass Alavi, Hongming Zhuang

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Whole-body fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) has been useful in the management of a variety of malignancies. In patients with chemotherapy followed by bone marrow stimulants such as granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor, the bone marrow will have diffuse, increased FDG accumulation. Therefore, diffuse bone marrow FDG uptake is commonly attributable to the effect of hematopoietic cytokines. However, diffuse bone marrow FDG uptake can also be caused by bone marrow involvement by malignancy. The authors report a patient with diffuse bone marrow involvement of Hodgkin disease that appears indistinguishable from hematopoietic cytokine-mediated FDG bone marrow uptake.

Original languageEnglish (US)
Pages (from-to)674-676
Number of pages3
JournalClinical Nuclear Medicine
Volume28
Issue number8
DOIs
StatePublished - Jan 1 2003

Keywords

  • Bone marrow
  • Cytokine
  • FDG PET
  • Hodgkin lymphoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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