Differentiation status modulates transcription factor NF-κB activity in unstimulated human hepatocellular carcinoma cell lines

Tsan Zon Liu, Chih Chi Andrew Hu, Yuang Hsiang Chen, Arnold Stern, Jiin Tsuey Cheng

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We report herein a novel finding that under an unstimulated condition, a group of four human hepatocellular carcinoma (HCC) cell lines with varying degrees of differentiation, can spontaneously activate NF-κB. The propensity of activation coincided inversely with the differentiation status, with order being SK-Hep-1 > J5 > Hep3B > HepG2. Further studies indicate that this pattern of activation correlates excellently with the descending order of intracellular GSH/GSSG ratios as well as with the ascending order in the ability of these cells to generate hydrogen peroxide. Taken together, our data suggest that differentiation status may play a pivotal role in modulating intracellular thiol redox status and the extent of catalase expression, which may be crucial in the control of NF-κB activity in these HCC cells. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalCancer Letters
Volume151
Issue number1
DOIs
StatePublished - Apr 3 2000

Keywords

  • Constitutive HO generation
  • Differentiation
  • Thiol redox status
  • Transcriptional factor NF-κB

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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