Differential effect of repeated treatment with l-DOPA on dopamine-D1 or -D2 receptors

M. Parenti, C. Flauto, E. Parati, Angelo Vescovi, A. Groppetti

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Unilateral degeneration of the nigro-striatal dopaminergic pathway with 6-hydroxydopamine induced controlateral rotations to apomorphine injection, increased [3H]spiroperidol binding and enhanced sensitivity of adenylate cyclase to dopamine stimulation in lesioned striata. Prolonged L-DOPA administration counteracted the increased density of [3H]-spiroperidol binding sites but further enhanced the hypersensitivity of adenylate cyclase to dopamine. Also apomorphine-induced controlateral rotations were potentiated. This effect was antagonized by SCH-23390. These results suggest that dopaminergic D1 and D2 receptors are differently affected by prolonged L-DOPA treatment. This study was supported by grants from Italian CNR and MPI.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalNeuropharmacology
Volume25
Issue number3
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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