Differential effect of recombinant human leukocyte interferon on human leukemic and normal myeloid progenitor cells

Steven Grant; Kapil Bhalla; I. Bernard Weinstein; Sidney Pestka; Paul B. Fisher

doi:10.1016/0006-291X(82)92105-2

Differential effect of recombinant human leukocyte interferon on human leukemic and normal myeloid progenitor cells

Steven Grant, Kapil Bhalla, I. Bernard Weinstein, Sidney Pestka, Paul B. Fisher

Dr. Mary and Ron Neal Cancer Center

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Two separate clones of recombinant leukocyte interferon (IFLrA and IFLrD) inhibited the cloning efficiency in soft agar of the human leukemia cell lines HL-60 and KG-1. Inhibition of the growth in agar of normal human bone marrow myeloid progenitors was also observed, but this required considerably higher concentrations. IFLrA and IFLrD also inhibited the growth of HL-60 and KG-1 cells in suspension culture. This antiproliferative effect did not appear to be due to induction of maturation of these cells. Our results suggest that homogeneous preparations of interferon may be capable of exerting selective antiproliferative effects on malignant human myeloid progenitor cells in comparison to their normal counterparts.

Original language	English (US)
Pages (from-to)	1048-1055
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(82)92105-2
State	Published - Oct 15 1982

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "Two separate clones of recombinant leukocyte interferon (IFLrA and IFLrD) inhibited the cloning efficiency in soft agar of the human leukemia cell lines HL-60 and KG-1. Inhibition of the growth in agar of normal human bone marrow myeloid progenitors was also observed, but this required considerably higher concentrations. IFLrA and IFLrD also inhibited the growth of HL-60 and KG-1 cells in suspension culture. This antiproliferative effect did not appear to be due to induction of maturation of these cells. Our results suggest that homogeneous preparations of interferon may be capable of exerting selective antiproliferative effects on malignant human myeloid progenitor cells in comparison to their normal counterparts.",

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AU - Grant, Steven

AU - Bhalla, Kapil

AU - Weinstein, I. Bernard

AU - Pestka, Sidney

AU - Fisher, Paul B.

PY - 1982/10/15

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N2 - Two separate clones of recombinant leukocyte interferon (IFLrA and IFLrD) inhibited the cloning efficiency in soft agar of the human leukemia cell lines HL-60 and KG-1. Inhibition of the growth in agar of normal human bone marrow myeloid progenitors was also observed, but this required considerably higher concentrations. IFLrA and IFLrD also inhibited the growth of HL-60 and KG-1 cells in suspension culture. This antiproliferative effect did not appear to be due to induction of maturation of these cells. Our results suggest that homogeneous preparations of interferon may be capable of exerting selective antiproliferative effects on malignant human myeloid progenitor cells in comparison to their normal counterparts.

AB - Two separate clones of recombinant leukocyte interferon (IFLrA and IFLrD) inhibited the cloning efficiency in soft agar of the human leukemia cell lines HL-60 and KG-1. Inhibition of the growth in agar of normal human bone marrow myeloid progenitors was also observed, but this required considerably higher concentrations. IFLrA and IFLrD also inhibited the growth of HL-60 and KG-1 cells in suspension culture. This antiproliferative effect did not appear to be due to induction of maturation of these cells. Our results suggest that homogeneous preparations of interferon may be capable of exerting selective antiproliferative effects on malignant human myeloid progenitor cells in comparison to their normal counterparts.

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Differential effect of recombinant human leukocyte interferon on human leukemic and normal myeloid progenitor cells

Abstract

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