Differential effect of recombinant human leukocyte interferon on human leukemic and normal myeloid progenitor cells

Steven Grant, Kapil Bhalla, I. Bernard Weinstein, Sidney Pestka, Paul B. Fisher

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Two separate clones of recombinant leukocyte interferon (IFLrA and IFLrD) inhibited the cloning efficiency in soft agar of the human leukemia cell lines HL-60 and KG-1. Inhibition of the growth in agar of normal human bone marrow myeloid progenitors was also observed, but this required considerably higher concentrations. IFLrA and IFLrD also inhibited the growth of HL-60 and KG-1 cells in suspension culture. This antiproliferative effect did not appear to be due to induction of maturation of these cells. Our results suggest that homogeneous preparations of interferon may be capable of exerting selective antiproliferative effects on malignant human myeloid progenitor cells in comparison to their normal counterparts.

Original languageEnglish (US)
Pages (from-to)1048-1055
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume108
Issue number3
DOIs
StatePublished - Oct 15 1982

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Differential effect of recombinant human leukocyte interferon on human leukemic and normal myeloid progenitor cells'. Together they form a unique fingerprint.

Cite this