Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain

Marie Österlund; George G.j.m. Kuiper; Jan Åke Gustafsson; Yasmin L. Hurd

doi:10.1016/S0169-328X(97)00351-3

Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain

Marie Österlund, George G.j.m. Kuiper, Jan Åke Gustafsson, Yasmin L. Hurd

Research output: Contribution to journal › Article › peer-review

321 Scopus citations

Abstract

In the present study, estrogen receptor (ER)α and ERβ genes were found to be differentially expressed in discrete subregions of the rat amygdaloid complex. The amygdala nuclei showing predominant ERα mRNA expression included the posterolateral cortical nucleus, amygdala hippocampal area, and lateral dorsolateral nucleus, whereas the amygdala areas with predominant ERβ mRNA expression were the medial anterodorsal and central nuclei. Both ERα and ERβ mRNAs were highly expressed in the medial posterodorsal nucleus. In addition to the discrete anatomical expression patterns, there appeared to be a differential regulation by estradiol of the ERα and ERβ mRNAs. Two weeks of estradiol (170 μg total) treatment decreased ERα mRNA expression levels in the arcuate, ventromedial hypothalamus, and posterolateral cortical amygdala nucleus, but increased ERβ mRNA in the arcuate. In the medial amygdala nuclei, only ERβ mRNA levels were altered (reduced) by estradiol treatment. These results suggest that estrogen can modulate behaviors and functions mediated by the amygdala and hypothalamus via differentially regulated ER subtypes.

Original language	English (US)
Pages (from-to)	175-180
Number of pages	6
Journal	Molecular Brain Research
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/S0169-328X(97)00351-3
State	Published - Feb 1998

Keywords

17β-estradiol
Amygdala
Hypothalamus
In situ hybridization
Steroid hormone

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(97)00351-3

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title = "Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain",

abstract = "In the present study, estrogen receptor (ER)α and ERβ genes were found to be differentially expressed in discrete subregions of the rat amygdaloid complex. The amygdala nuclei showing predominant ERα mRNA expression included the posterolateral cortical nucleus, amygdala hippocampal area, and lateral dorsolateral nucleus, whereas the amygdala areas with predominant ERβ mRNA expression were the medial anterodorsal and central nuclei. Both ERα and ERβ mRNAs were highly expressed in the medial posterodorsal nucleus. In addition to the discrete anatomical expression patterns, there appeared to be a differential regulation by estradiol of the ERα and ERβ mRNAs. Two weeks of estradiol (170 μg total) treatment decreased ERα mRNA expression levels in the arcuate, ventromedial hypothalamus, and posterolateral cortical amygdala nucleus, but increased ERβ mRNA in the arcuate. In the medial amygdala nuclei, only ERβ mRNA levels were altered (reduced) by estradiol treatment. These results suggest that estrogen can modulate behaviors and functions mediated by the amygdala and hypothalamus via differentially regulated ER subtypes.",

keywords = "17β-estradiol, Amygdala, Hypothalamus, In situ hybridization, Steroid hormone",

author = "Marie {\"O}sterlund and {G.j.m. Kuiper}, George and Gustafsson, {Jan {\AA}ke} and Hurd, {Yasmin L.}",

note = "Funding Information: We thank Ms. Haleh Razani and Prof. Sven-Ove {\"O}gren for generously sharing technical services with handling the animals and Ms. Siv Eriksson for technical assistance. This work was supported by grants from the Stiftelsen S{\"o}derstr{\"o}m K{\"o}nigska Sjukhemmet, Fredrik och Ingrid Thurings Stiftelse, and Kapten Arthur Erikssons Stiftelse. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S0169-328X(97)00351-3",

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AU - Hurd, Yasmin L.

N1 - Funding Information: We thank Ms. Haleh Razani and Prof. Sven-Ove Ögren for generously sharing technical services with handling the animals and Ms. Siv Eriksson for technical assistance. This work was supported by grants from the Stiftelsen Söderström Königska Sjukhemmet, Fredrik och Ingrid Thurings Stiftelse, and Kapten Arthur Erikssons Stiftelse. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1998/2

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N2 - In the present study, estrogen receptor (ER)α and ERβ genes were found to be differentially expressed in discrete subregions of the rat amygdaloid complex. The amygdala nuclei showing predominant ERα mRNA expression included the posterolateral cortical nucleus, amygdala hippocampal area, and lateral dorsolateral nucleus, whereas the amygdala areas with predominant ERβ mRNA expression were the medial anterodorsal and central nuclei. Both ERα and ERβ mRNAs were highly expressed in the medial posterodorsal nucleus. In addition to the discrete anatomical expression patterns, there appeared to be a differential regulation by estradiol of the ERα and ERβ mRNAs. Two weeks of estradiol (170 μg total) treatment decreased ERα mRNA expression levels in the arcuate, ventromedial hypothalamus, and posterolateral cortical amygdala nucleus, but increased ERβ mRNA in the arcuate. In the medial amygdala nuclei, only ERβ mRNA levels were altered (reduced) by estradiol treatment. These results suggest that estrogen can modulate behaviors and functions mediated by the amygdala and hypothalamus via differentially regulated ER subtypes.

AB - In the present study, estrogen receptor (ER)α and ERβ genes were found to be differentially expressed in discrete subregions of the rat amygdaloid complex. The amygdala nuclei showing predominant ERα mRNA expression included the posterolateral cortical nucleus, amygdala hippocampal area, and lateral dorsolateral nucleus, whereas the amygdala areas with predominant ERβ mRNA expression were the medial anterodorsal and central nuclei. Both ERα and ERβ mRNAs were highly expressed in the medial posterodorsal nucleus. In addition to the discrete anatomical expression patterns, there appeared to be a differential regulation by estradiol of the ERα and ERβ mRNAs. Two weeks of estradiol (170 μg total) treatment decreased ERα mRNA expression levels in the arcuate, ventromedial hypothalamus, and posterolateral cortical amygdala nucleus, but increased ERβ mRNA in the arcuate. In the medial amygdala nuclei, only ERβ mRNA levels were altered (reduced) by estradiol treatment. These results suggest that estrogen can modulate behaviors and functions mediated by the amygdala and hypothalamus via differentially regulated ER subtypes.

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Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain

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Keywords

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