TY - JOUR
T1 - Differential carcinogenicity of benzo[a]pyrene in male and female cd-1 mouse lung
AU - Sharma, Rashmi
AU - Haque, Abida K.
AU - Awasthi, Sanjay
AU - Singh, Shivendra V.
AU - Piper, John T.
AU - Awasthi, Yogesh C.
N1 - Funding Information:
Received 10 October 1996; sent for revision 22 November 1996; accepted 13 December 1996. The authors thank Rochelle Simmons for technical assistance and Alicia Woods for help in preparation of this manuscript. This investigation was supported in part by U.S. Public Health Service grants CA27967 awarded to Y. C. Awasthi, CA63660 to S. Awasthi, and CA55589 to S. V. Singh by the National Cancer Institute. Address correspondence to Yogesh C. Awasthi, PhD, Department of Human Biological Chemistry and Genetics, 7.138 Medical Research Bldg., University of Texas Medical Branch, Galveston, TX 77555-1 067, USA.
PY - 1997/9
Y1 - 1997/9
N2 - Benzo[a]pyrene (BaP) is known to induce tumors in lung, forestomach, and skin in experimental animals. Earlier studies have suggested that glutathione S-transferase π (CST pi) is involved in the detoxification of the 'ultimate' carcinogenic metabolite of BaP, 7β, 8α-dihydroxy-9α, 10α-oxy-7,8,9, 10-tetrahydrobenzo[a]pyrene (BPDE). The constitutive expression of CST pi in the liver of the male CD-1 mouse is higher than that of the female, and BHA has been shown to preferentially induce CST pi in the female as compared with the male mouse. The present studies were therefore designed to compare the susceptibility of male and female CD-1 mice to the carcinogenic effects of BaP and the protective effect of BHA. Results of these studies show that the female CD-1 mice are more susceptibile to the carcinogenic effect of BaP than the males and that the attenuation of BaP-induced carcinogenesis by BHA appears to be restricted only to the females.
AB - Benzo[a]pyrene (BaP) is known to induce tumors in lung, forestomach, and skin in experimental animals. Earlier studies have suggested that glutathione S-transferase π (CST pi) is involved in the detoxification of the 'ultimate' carcinogenic metabolite of BaP, 7β, 8α-dihydroxy-9α, 10α-oxy-7,8,9, 10-tetrahydrobenzo[a]pyrene (BPDE). The constitutive expression of CST pi in the liver of the male CD-1 mouse is higher than that of the female, and BHA has been shown to preferentially induce CST pi in the female as compared with the male mouse. The present studies were therefore designed to compare the susceptibility of male and female CD-1 mice to the carcinogenic effects of BaP and the protective effect of BHA. Results of these studies show that the female CD-1 mice are more susceptibile to the carcinogenic effect of BaP than the males and that the attenuation of BaP-induced carcinogenesis by BHA appears to be restricted only to the females.
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U2 - 10.1080/00984109708984052
DO - 10.1080/00984109708984052
M3 - Article
C2 - 9269322
AN - SCOPUS:0030805598
VL - 52
SP - 45
EP - 62
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
SN - 0098-4108
IS - 1
ER -