TY - JOUR
T1 - Different Risk Factors for Graft Survival Between Living-Related and Deceased Donor Kidney Transplantation
AU - Zhang, H.
AU - Wei, Y.
AU - Liu, L.
AU - Li, J.
AU - Deng, R.
AU - Xiong, Y.
AU - Yuan, X.
AU - He, X.
AU - Fu, Q.
AU - Wang, C.
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (No. 81670680 , 81300623 , 81700655 ), Science and Technology Planning Project of Guangdong Province, China (2015B020226002, 2014B020212006, 2013B021800292, 2014A020212719), the Natural Science Foundation of Guangdong Province ( 2015A030313135 , 2014A030313022 ), Science and Technology Program of Guangzhou, China (2014Y2-00114), and the Guangdong Provincial Key Laboratory on Organ Donation and Transplant Immunology (2013A 061401007). We thank Fangchao Yu for his meticulous work on clinical data collection.
Publisher Copyright:
© 2018
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - The aim of this study was to determine distinctive risk factors for graft survival of living-related and deceased donor kidney transplantation (KTx). Methods: Consecutive 536 living-related and 524 deceased donor kidney transplant recipients from February 2014 to December 2015 in a single center were enrolled for retrospective analysis. Graft survival was assessed with the Kaplan-Meier method, and the Cox proportional hazard model was used to determine independent risk factors of allograft survival. Results: One-, 3-, and 5-year graft survival rates were 98.8%, 98.5%, and 97.2%, respectively, in living-related donor KTx and were 94.9%, 91.3%, and 91.3%, respectively, in deceased donor KTx (log-rank, P <.001). Multivariate analysis demonstrated that risk factors for graft survival in living-related donor KTx were pretransplant dialysis duration (hazard ratio [HR], 1.023 per month; P =.046), delayed graft function (HR, 5.785; P =.02), and acute rejection (HR, 2.706; P =.04); risks factors in deceased donor KTx were recipient age (HR, 1.066 per year; P =.004), recipient history of diabetes mellitus (HR, 3.011; P =.03), pretransplant positive panel reactive antibody (HR, 3.353; P =.02), and donor history of hypertension (HR, 2.660; P =.046). Conclusion: Distinctive risk factors for graft survival of living-related and deceased donor KTx were found.
AB - The aim of this study was to determine distinctive risk factors for graft survival of living-related and deceased donor kidney transplantation (KTx). Methods: Consecutive 536 living-related and 524 deceased donor kidney transplant recipients from February 2014 to December 2015 in a single center were enrolled for retrospective analysis. Graft survival was assessed with the Kaplan-Meier method, and the Cox proportional hazard model was used to determine independent risk factors of allograft survival. Results: One-, 3-, and 5-year graft survival rates were 98.8%, 98.5%, and 97.2%, respectively, in living-related donor KTx and were 94.9%, 91.3%, and 91.3%, respectively, in deceased donor KTx (log-rank, P <.001). Multivariate analysis demonstrated that risk factors for graft survival in living-related donor KTx were pretransplant dialysis duration (hazard ratio [HR], 1.023 per month; P =.046), delayed graft function (HR, 5.785; P =.02), and acute rejection (HR, 2.706; P =.04); risks factors in deceased donor KTx were recipient age (HR, 1.066 per year; P =.004), recipient history of diabetes mellitus (HR, 3.011; P =.03), pretransplant positive panel reactive antibody (HR, 3.353; P =.02), and donor history of hypertension (HR, 2.660; P =.046). Conclusion: Distinctive risk factors for graft survival of living-related and deceased donor KTx were found.
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U2 - 10.1016/j.transproceed.2018.03.047
DO - 10.1016/j.transproceed.2018.03.047
M3 - Article
C2 - 30316369
AN - SCOPUS:85054462153
SN - 0041-1345
VL - 50
SP - 2416
EP - 2420
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 8
ER -