Different Risk Factors for Graft Survival Between Living-Related and Deceased Donor Kidney Transplantation

H. Zhang, Y. Wei, L. Liu, J. Li, R. Deng, Y. Xiong, X. Yuan, X. He, Q. Fu, C. Wang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The aim of this study was to determine distinctive risk factors for graft survival of living-related and deceased donor kidney transplantation (KTx). Methods: Consecutive 536 living-related and 524 deceased donor kidney transplant recipients from February 2014 to December 2015 in a single center were enrolled for retrospective analysis. Graft survival was assessed with the Kaplan-Meier method, and the Cox proportional hazard model was used to determine independent risk factors of allograft survival. Results: One-, 3-, and 5-year graft survival rates were 98.8%, 98.5%, and 97.2%, respectively, in living-related donor KTx and were 94.9%, 91.3%, and 91.3%, respectively, in deceased donor KTx (log-rank, P <.001). Multivariate analysis demonstrated that risk factors for graft survival in living-related donor KTx were pretransplant dialysis duration (hazard ratio [HR], 1.023 per month; P =.046), delayed graft function (HR, 5.785; P =.02), and acute rejection (HR, 2.706; P =.04); risks factors in deceased donor KTx were recipient age (HR, 1.066 per year; P =.004), recipient history of diabetes mellitus (HR, 3.011; P =.03), pretransplant positive panel reactive antibody (HR, 3.353; P =.02), and donor history of hypertension (HR, 2.660; P =.046). Conclusion: Distinctive risk factors for graft survival of living-related and deceased donor KTx were found.

Original languageEnglish (US)
Pages (from-to)2416-2420
Number of pages5
JournalTransplantation Proceedings
Volume50
Issue number8
DOIs
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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