Different genetic impact in the development of renal length and width: A twin study

Research output: Contribution to journalArticle

D. L. Tarnoki, A. D. Tarnoki, P. Bata, L. Littvay, Z. Garami, V. Berczi, K. Karlinger

Background: Ultrasound measurements of renal dimensions are conventionally limited to renal length, shape and cortical thickness. These are regarded as adequate for normal therapeutic decision-making and volume measurements are reserved for a few clinical trials. However, there is no evidence concerning the degree to which renal length or volume is independently susceptible to heritable and environmental influences. Aim: We aimed to determine whether renal length or width (as a surrogate of volume) was more influenced by heritability. Methods: A single operator measured renal length and width in 114 adult monozygotic and same-sex dizygotic Hungarian twin pairs (mean age 43.6 ± 16.3 years), using an Esaote MyLab 70X ultrasound machine with curved array transducer (1-8MHz, CA431). Results: Analysis of within-pair co-twin correlations adjusted for age and gender showed that the age- and sex-adjusted heritability of average renal length was 51% (95% confidence interval, 29-72%). Renal width showed negligible genetic influence. Common environmental effects had no influence, and unshared environments were responsible for 49-80% of the variance, mainly renal width. Conclusions: This study is the first to demonstrate the moderate heritability and limited environmental influence on renal length, and the contrasting lack of heritability of renal width, which is mainly influenced by unshared environmental components, that is lifestyle habits. Renal width therefore better represents the influence of modifiable environmental factors than renal length. The results suggest that renal width not length should be reported to facilitate early detection and monitoring of renal disease.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalInternal Medicine Journal
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2015

PMID: 25370129

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Different genetic impact in the development of renal length and width : A twin study. / Tarnoki, D. L.; Tarnoki, A. D.; Bata, P.; Littvay, L.; Garami, Z.; Berczi, V.; Karlinger, K.

In: Internal Medicine Journal, Vol. 45, No. 1, 01.01.2015, p. 63-67.

Research output: Contribution to journalArticle

Harvard

Tarnoki, DL, Tarnoki, AD, Bata, P, Littvay, L, Garami, Z, Berczi, V & Karlinger, K 2015, 'Different genetic impact in the development of renal length and width: A twin study' Internal Medicine Journal, vol. 45, no. 1, pp. 63-67. https://doi.org/10.1111/imj.12631

APA

Tarnoki, D. L., Tarnoki, A. D., Bata, P., Littvay, L., Garami, Z., Berczi, V., & Karlinger, K. (2015). Different genetic impact in the development of renal length and width: A twin study. Internal Medicine Journal, 45(1), 63-67. https://doi.org/10.1111/imj.12631

Vancouver

Tarnoki DL, Tarnoki AD, Bata P, Littvay L, Garami Z, Berczi V et al. Different genetic impact in the development of renal length and width: A twin study. Internal Medicine Journal. 2015 Jan 1;45(1):63-67. https://doi.org/10.1111/imj.12631

Author

Tarnoki, D. L. ; Tarnoki, A. D. ; Bata, P. ; Littvay, L. ; Garami, Z. ; Berczi, V. ; Karlinger, K. / Different genetic impact in the development of renal length and width : A twin study. In: Internal Medicine Journal. 2015 ; Vol. 45, No. 1. pp. 63-67.

BibTeX

@article{a6a1136064c649aa8e534dc18e3a8b38,
title = "Different genetic impact in the development of renal length and width: A twin study",
abstract = "Background: Ultrasound measurements of renal dimensions are conventionally limited to renal length, shape and cortical thickness. These are regarded as adequate for normal therapeutic decision-making and volume measurements are reserved for a few clinical trials. However, there is no evidence concerning the degree to which renal length or volume is independently susceptible to heritable and environmental influences. Aim: We aimed to determine whether renal length or width (as a surrogate of volume) was more influenced by heritability. Methods: A single operator measured renal length and width in 114 adult monozygotic and same-sex dizygotic Hungarian twin pairs (mean age 43.6 ± 16.3 years), using an Esaote MyLab 70X ultrasound machine with curved array transducer (1-8MHz, CA431). Results: Analysis of within-pair co-twin correlations adjusted for age and gender showed that the age- and sex-adjusted heritability of average renal length was 51{\%} (95{\%} confidence interval, 29-72{\%}). Renal width showed negligible genetic influence. Common environmental effects had no influence, and unshared environments were responsible for 49-80{\%} of the variance, mainly renal width. Conclusions: This study is the first to demonstrate the moderate heritability and limited environmental influence on renal length, and the contrasting lack of heritability of renal width, which is mainly influenced by unshared environmental components, that is lifestyle habits. Renal width therefore better represents the influence of modifiable environmental factors than renal length. The results suggest that renal width not length should be reported to facilitate early detection and monitoring of renal disease.",
keywords = "Heritability, Lifestyle, Renal length, Sonography, Twin",
author = "Tarnoki, {D. L.} and Tarnoki, {A. D.} and P. Bata and L. Littvay and Z. Garami and V. Berczi and K. Karlinger",
year = "2015",
month = "1",
day = "1",
doi = "10.1111/imj.12631",
language = "English (US)",
volume = "45",
pages = "63--67",
journal = "Internal Medicine Journal",
issn = "1444-0903",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Different genetic impact in the development of renal length and width

T2 - Internal Medicine Journal

AU - Tarnoki, D. L.

AU - Tarnoki, A. D.

AU - Bata, P.

AU - Littvay, L.

AU - Garami, Z.

AU - Berczi, V.

AU - Karlinger, K.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Ultrasound measurements of renal dimensions are conventionally limited to renal length, shape and cortical thickness. These are regarded as adequate for normal therapeutic decision-making and volume measurements are reserved for a few clinical trials. However, there is no evidence concerning the degree to which renal length or volume is independently susceptible to heritable and environmental influences. Aim: We aimed to determine whether renal length or width (as a surrogate of volume) was more influenced by heritability. Methods: A single operator measured renal length and width in 114 adult monozygotic and same-sex dizygotic Hungarian twin pairs (mean age 43.6 ± 16.3 years), using an Esaote MyLab 70X ultrasound machine with curved array transducer (1-8MHz, CA431). Results: Analysis of within-pair co-twin correlations adjusted for age and gender showed that the age- and sex-adjusted heritability of average renal length was 51% (95% confidence interval, 29-72%). Renal width showed negligible genetic influence. Common environmental effects had no influence, and unshared environments were responsible for 49-80% of the variance, mainly renal width. Conclusions: This study is the first to demonstrate the moderate heritability and limited environmental influence on renal length, and the contrasting lack of heritability of renal width, which is mainly influenced by unshared environmental components, that is lifestyle habits. Renal width therefore better represents the influence of modifiable environmental factors than renal length. The results suggest that renal width not length should be reported to facilitate early detection and monitoring of renal disease.

AB - Background: Ultrasound measurements of renal dimensions are conventionally limited to renal length, shape and cortical thickness. These are regarded as adequate for normal therapeutic decision-making and volume measurements are reserved for a few clinical trials. However, there is no evidence concerning the degree to which renal length or volume is independently susceptible to heritable and environmental influences. Aim: We aimed to determine whether renal length or width (as a surrogate of volume) was more influenced by heritability. Methods: A single operator measured renal length and width in 114 adult monozygotic and same-sex dizygotic Hungarian twin pairs (mean age 43.6 ± 16.3 years), using an Esaote MyLab 70X ultrasound machine with curved array transducer (1-8MHz, CA431). Results: Analysis of within-pair co-twin correlations adjusted for age and gender showed that the age- and sex-adjusted heritability of average renal length was 51% (95% confidence interval, 29-72%). Renal width showed negligible genetic influence. Common environmental effects had no influence, and unshared environments were responsible for 49-80% of the variance, mainly renal width. Conclusions: This study is the first to demonstrate the moderate heritability and limited environmental influence on renal length, and the contrasting lack of heritability of renal width, which is mainly influenced by unshared environmental components, that is lifestyle habits. Renal width therefore better represents the influence of modifiable environmental factors than renal length. The results suggest that renal width not length should be reported to facilitate early detection and monitoring of renal disease.

KW - Heritability

KW - Lifestyle

KW - Renal length

KW - Sonography

KW - Twin

UR - http://www.scopus.com/inward/record.url?scp=84920985079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920985079&partnerID=8YFLogxK

U2 - 10.1111/imj.12631

DO - 10.1111/imj.12631

M3 - Article

VL - 45

SP - 63

EP - 67

JO - Internal Medicine Journal

JF - Internal Medicine Journal

SN - 1444-0903

IS - 1

ER -

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