Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow

C. J.H. Porter; S. M. Moghimi; M. C. Davies; S. S. Davis; L. Illum

doi:10.1016/0378-5173(82)90033-3

Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow

C. J.H. Porter, S. M. Moghimi, M. C. Davies, S. S. Davis, L. Illum

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.

Original language	English (US)
Pages (from-to)	273-276
Number of pages	4
Journal	International Journal of Pharmaceutics
Volume	83
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(82)90033-3
State	Published - Jun 30 1992

Keywords

Bone marrow
Microsphere
Poloxamer 407
Rabbit
Rat

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/0378-5173(82)90033-3

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title = "Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow",

abstract = "Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.",

keywords = "Bone marrow, Microsphere, Poloxamer 407, Rabbit, Rat",

author = "Porter, \{C. J.H.\} and Moghimi, \{S. M.\} and Davies, \{M. C.\} and Davis, \{S. S.\} and L. Illum",

note = "Funding Information: We are grateful to RAPRA Technology Ltd, Shrewsbury, U.K., for their help in performing raised temperature gel-permeation chromatography, Professor E. Schacht, Laboratory of Organic Chemistry, Rijksuniversiteit Gent, Belgium, for his expert assistance with the NMR studies, and to the SERC, U.K., for financial support. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "1992",

month = jun,

day = "30",

doi = "10.1016/0378-5173(82)90033-3",

language = "English (US)",

volume = "83",

pages = "273--276",

journal = "International Journal of Pharmaceutics",

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T1 - Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow

AU - Porter, C. J.H.

AU - Moghimi, S. M.

AU - Davies, M. C.

AU - Davis, S. S.

AU - Illum, L.

N1 - Funding Information: We are grateful to RAPRA Technology Ltd, Shrewsbury, U.K., for their help in performing raised temperature gel-permeation chromatography, Professor E. Schacht, Laboratory of Organic Chemistry, Rijksuniversiteit Gent, Belgium, for his expert assistance with the NMR studies, and to the SERC, U.K., for financial support. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 1992/6/30

Y1 - 1992/6/30

N2 - Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.

AB - Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.

KW - Bone marrow

KW - Microsphere

KW - Poloxamer 407

KW - Rabbit

KW - Rat

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JF - International Journal of Pharmaceutics

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ER -

Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow

Abstract

Keywords

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